(+)-(2S,3R)-2-<(methanesulfonyl)-oxy>methyl-3-methyl-1-methylidene-3-p-tolyl-cyclopentane

Base Information

Chemical Name:(+)-(2S,3R)-2-<(methanesulfonyl)-oxy>methyl-3-methyl-1-methylidene-3-p-tolyl-cyclopentane
CAS No.:246039-83-8
Molecular Formula:C₁₆H₂₂O₃S
Molecular Weight:294.415
Hs Code.:

Synonyms:(+)-(2S,3R)-2-<(methanesulfonyl)-oxy>methyl-3-methyl-1-methylidene-3-p-tolyl-cyclopentane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(2S,3R)-2-<(methanesulfonyl)-oxy>methyl-3-methyl-1-methylidene-3-p-tolyl-cyclopentane

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Technology Process of (+)-(2S,3R)-2-<(methanesulfonyl)-oxy>methyl-3-methyl-1-methylidene-3-p-tolyl-cyclopentane

There total 5 articles about (+)-(2S,3R)-2-<(methanesulfonyl)-oxy>methyl-3-methyl-1-methylidene-3-p-tolyl-cyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 124-63-0
methanesulfonyl chloride

: 246039-81-6
(+)-(2S,3R)-2-hydroxymethyl-3-methyl-1-methylidene-3-p-tolyl-cyclopentane

: 246039-83-8
(+)-(2S,3R)-2-<(methanesulfonyl)-oxy>methyl-3-methyl-1-methylidene-3-p-tolyl-cyclopentane

Guidance literature:: With pyridine; for 1h; Ambient temperature;
DOI:10.1016/S0957-4166(99)00195-0

Reference yield:

: 2758-18-1
3-Methyl-2-cyclopenten-1-one

: 246039-83-8
(+)-(2S,3R)-2-<(methanesulfonyl)-oxy>methyl-3-methyl-1-methylidene-3-p-tolyl-cyclopentane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) cuprous bromide-dimethylsulfide complex, 2.) hexamethylphosphoric triamide / 1.) THF, -5 deg C, 2 h, 2.) THF, RT, 15 h

2: 91 percent / Ni(acac)2 / tetrahydrofuran; diethyl ether / 2 h / Heating

3: Me₂AlCl, 4 Angstroem molecular sieves / CH₂Cl₂; hexane / 1 h / -10 °C

4: 98 percent / pyridine / 1 h / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; bis(acetylacetonate)nickel(II); copper(I) bromide dimethylsulfide complex; 4 A molecular sieve; dimethylaluminum chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1016/S0957-4166(99)00195-0

Reference yield:

: 4294-57-9
para-methylphenylmagnesium bromide

: 246039-83-8
(+)-(2S,3R)-2-<(methanesulfonyl)-oxy>methyl-3-methyl-1-methylidene-3-p-tolyl-cyclopentane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) cuprous bromide-dimethylsulfide complex, 2.) hexamethylphosphoric triamide / 1.) THF, -5 deg C, 2 h, 2.) THF, RT, 15 h

2: 91 percent / Ni(acac)2 / tetrahydrofuran; diethyl ether / 2 h / Heating

3: Me₂AlCl, 4 Angstroem molecular sieves / CH₂Cl₂; hexane / 1 h / -10 °C

4: 98 percent / pyridine / 1 h / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; bis(acetylacetonate)nickel(II); copper(I) bromide dimethylsulfide complex; 4 A molecular sieve; dimethylaluminum chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1016/S0957-4166(99)00195-0