4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid

Base Information

• Chemical Name: 4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid
• CAS No.: 1354541-47-1
• Molecular Formula: C₁₄H₉F₂N₃O₂S
• Molecular Weight: 321.307

Synonyms:4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid

Chemical Property of 4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid

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Technology Process of 4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid

There total 2 articles about 4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (422560-58-5) → 4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid (1354541-47-1)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2012.10.007

Reference yield:

ethyl 2-amino-3-cyano-4-methylthiophene-5-carboxylate (23903-46-0) → 4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid (1354541-47-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / toluene / Reflux

2: acetic acid / 4 h / Reflux

3: sodium hydroxide; water / methanol / 16 h / 20 °C

With water; acetic acid; sodium hydroxide; In methanol; toluene;

DOI:10.1016/j.ejmech.2012.10.007

Reference yield: 81.0%

4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid (1354541-47-1) + 4-chlorobenzoic acid hydrazide (536-40-3) → C21H12ClF2N5OS (1416273-89-6)

Guidance literature:

With trichlorophosphate; for 5h; Reflux;

DOI:10.1016/j.ejmech.2012.10.007

upstream raw materials:

ethyl 4-(2,4-difluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate

ethyl 2-amino-3-cyano-4-methylthiophene-5-carboxylate

Downstream raw materials:

C₂₁H₁₃F₂N₅OS

C₂₁H₁₂ClF₂N₅OS

C₂₁H₁₂F₂N₆O₃S

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