1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

Base Information

Chemical Name:1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea
CAS No.:1401344-79-3
Molecular Formula:C₂₆H₂₇N₅O₅
Molecular Weight:489.531
Hs Code.:

Synonyms:1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

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Chemical Property of 1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

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Technology Process of 1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

There total 6 articles about 1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1401344-78-2
1-((S)-1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

: 1401344-79-3
1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/c2cc34791a

Reference yield:

: 1401344-70-4
(S)-2-((3-nitrophenyl)amino)propan-1-ol

: 1401344-79-3
1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: dmap / dichloromethane / 48 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2cc34791a

Reference yield:

: (S)-1-(1-hydroxypropan-2-yl)-1-(3-nitrophenyl)-3-phenylurea

: 1401344-79-3
1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine; urea / tetrahydrofuran / 0.5 h / 20 °C

2: 5% Pd/C / ethanol / Inert atmosphere

3: sodium hydrogencarbonate / dichloromethane; water / Inert atmosphere

4: dmap / dichloromethane / 48 h / 20 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

With dmap; di-isopropyl azodicarboxylate; 5% Pd/C; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; acetic acid; triphenylphosphine; urea; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1039/c2cc34791a