(S)-3-(3-isocyanatophenyl)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)imidazolidin-2-one

Base Information

• Chemical Name: (S)-3-(3-isocyanatophenyl)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)imidazolidin-2-one
• CAS No.: 1401344-82-8
• Molecular Formula: C₂₇H₂₅N₅O₃
• Molecular Weight: 467.527

Synonyms:(S)-3-(3-isocyanatophenyl)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)imidazolidin-2-one

Chemical Property of (S)-3-(3-isocyanatophenyl)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)imidazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(3-isocyanatophenyl)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)imidazolidin-2-one

There total 9 articles about (S)-3-(3-isocyanatophenyl)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

bis(trichloromethyl) carbonate (32315-10-9) + (S)-3-(3-aminophenyl)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)imidazolidin-2-one (1401344-81-7) → (S)-3-(3-isocyanatophenyl)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)imidazolidin-2-one (1401344-82-8)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; Inert atmosphere;

DOI:10.1039/c2cc34791a

Reference yield:

N-(1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-3-nitroaniline (1401344-71-5) → (S)-3-(3-isocyanatophenyl)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)imidazolidin-2-one (1401344-82-8)

Guidance literature:

Multi-step reaction with 10 steps

1: dmap / dichloromethane / 48 h / 20 °C

2: tetrabutyl ammonium fluoride; acetic acid / 20 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine; urea / tetrahydrofuran / 0.5 h / 20 °C

4: 5% Pd/C / ethanol / Inert atmosphere

5: sodium hydrogencarbonate / dichloromethane; water / Inert atmosphere

6: dmap / dichloromethane / 48 h / 20 °C / Inert atmosphere

7: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

8: di-isopropyl azodicarboxylate; triphenylphosphine; urea / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

9: acetic acid; 5% Pd/C / ethanol; toluene / 3 h / Inert atmosphere

10: sodium hydrogencarbonate / dichloromethane; water / Inert atmosphere

With dmap; di-isopropyl azodicarboxylate; 5% Pd/C; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; acetic acid; triphenylphosphine; urea; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

DOI:10.1039/c2cc34791a

Reference yield:

phenyl isocyanate (103-71-9) → (S)-3-(3-isocyanatophenyl)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)imidazolidin-2-one (1401344-82-8)

Guidance literature:

Multi-step reaction with 10 steps

1: dmap / dichloromethane / 48 h / 20 °C

2: tetrabutyl ammonium fluoride; acetic acid / 20 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine; urea / tetrahydrofuran / 0.5 h / 20 °C

4: 5% Pd/C / ethanol / Inert atmosphere

5: sodium hydrogencarbonate / dichloromethane; water / Inert atmosphere

6: dmap / dichloromethane / 48 h / 20 °C / Inert atmosphere

7: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

8: di-isopropyl azodicarboxylate; triphenylphosphine; urea / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

9: acetic acid; 5% Pd/C / ethanol; toluene / 3 h / Inert atmosphere

10: sodium hydrogencarbonate / dichloromethane; water / Inert atmosphere

With dmap; di-isopropyl azodicarboxylate; 5% Pd/C; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; acetic acid; triphenylphosphine; urea; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

DOI:10.1039/c2cc34791a

upstream raw materials:

phenyl isocyanate

(S)-4-methyl-3-(3-nitrophenyl)-1-phenylimidazolidin-2-one

(S)-3-(3-aminophenyl)-4-methyl-1-phenylimidazolidin-2-one

bis(trichloromethyl) carbonate

Downstream raw materials:

1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

(S)-4-methyl-1-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-3-(3-((S)-4-methyl-3-(3-nitrophenyl)-2-oxoimidazolidin-1-yl)phenyl)imidazolidin-2-one

1-((S)-1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

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