[(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

Base Information

Chemical Name:[(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol
CAS No.:911705-46-9
Molecular Formula:C₂₀H₂₃NO₄S
Molecular Weight:373.473
Hs Code.:

Synonyms:[(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

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Chemical Property of [(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

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Technology Process of [(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

There total 5 articles about [(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911705-48-1
[(S)-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

: 98-59-9
p-toluenesulfonyl chloride

: 911705-46-9
[(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

Guidance literature:: With sodium carbonate; In water; ethyl acetate; at 0 ℃;

Reference yield:

: 6-oxo-4-(toluene-4-sulfonyloxy)-3,6-dihydro-2H-pyridine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

: 911705-46-9
[(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / palladium diacetate; XPhos / tetrahydrofuran / 2 h / 80 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 - 4 h / 70 °C

3.2: 0 °C

4.1: sodium carbonate / water; ethyl acetate / 0 °C

With hydrogenchloride; potassium phosphate; lithium aluminium tetrahydride; sodium carbonate; palladium diacetate; XPhos; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 911705-46-9
[(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / palladium diacetate; XPhos / tetrahydrofuran / 2 h / 80 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 - 4 h / 70 °C

3.2: 0 °C

4.1: sodium carbonate / water; ethyl acetate / 0 °C

With hydrogenchloride; potassium phosphate; lithium aluminium tetrahydride; sodium carbonate; palladium diacetate; XPhos; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;