(3R,4R,6S)-6-hydroxymethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol

Base Information

Chemical Name:(3R,4R,6S)-6-hydroxymethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol
CAS No.:911705-44-7
Molecular Formula:C₂₀H₂₅NO₅S
Molecular Weight:391.488
Hs Code.:

Synonyms:(3R,4R,6S)-6-hydroxymethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol

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Chemical Property of (3R,4R,6S)-6-hydroxymethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol

Chemical Property:

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Technology Process of (3R,4R,6S)-6-hydroxymethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol

There total 6 articles about (3R,4R,6S)-6-hydroxymethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911705-46-9
[(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

: 911705-44-7
(3R,4R,6S)-6-hydroxymethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol

Guidance literature:: [(S)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol; With borane-THF; In tetrahydrofuran; at 20 - 40 ℃; for 2 - 6h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water;

Reference yield:

: 6-oxo-4-(toluene-4-sulfonyloxy)-3,6-dihydro-2H-pyridine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

: 911705-44-7
(3R,4R,6S)-6-hydroxymethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate / palladium diacetate; XPhos / tetrahydrofuran / 2 h / 80 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 - 4 h / 70 °C

3.2: 0 °C

4.1: sodium carbonate / water; ethyl acetate / 0 °C

5.1: borane-THF / tetrahydrofuran / 2 - 6 h / 40 °C

5.2: 20 °C

With hydrogenchloride; potassium phosphate; lithium aluminium tetrahydride; borane-THF; sodium carbonate; palladium diacetate; XPhos; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 911705-44-7
(3R,4R,6S)-6-hydroxymethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate / palladium diacetate; XPhos / tetrahydrofuran / 2 h / 80 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 - 4 h / 70 °C

3.2: 0 °C

4.1: sodium carbonate / water; ethyl acetate / 0 °C

5.1: borane-THF / tetrahydrofuran / 2 - 6 h / 40 °C

5.2: 20 °C

With hydrogenchloride; potassium phosphate; lithium aluminium tetrahydride; borane-THF; sodium carbonate; palladium diacetate; XPhos; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;