4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine

Base Information

Chemical Name:4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine
CAS No.:1239963-62-2
Molecular Formula:C₂₅H₂₉ClFN₃OS
Molecular Weight:474.042
Hs Code.:

Synonyms:4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine

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Chemical Property of 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine

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Technology Process of 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine

There total 10 articles about 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239957-22-2
tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine-1-carboxylate

: 1239963-62-2
4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine

Guidance literature:: tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 1239963-78-0
2-(4-chloro-3-methoxyphenyl)-2-methylpropanoic acid

: 1239963-62-2
4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine

Guidance literature:: Multi-step reaction with 8 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

2: tetrahydrofuran / 2 h / -78 - 20 °C

3: tetra-N-butylammonium tribromide / methanol; dichloromethane / 3 h / 0 - 20 °C

4: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

5: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

6: acetic acid / 4 h / Reflux

7: potassium carbonate / acetone / 4 h / Reflux

8: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogenchloride; dmap; sodium azide; hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 850564-15-7
2-(4-Chloro-3-methoxy-phenyl)-2-methyl-propionitrile

: 1239963-62-2
4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)piperidine

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid; water / 20 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: tetrahydrofuran / 2 h / -78 - 20 °C

4: tetra-N-butylammonium tribromide / methanol; dichloromethane / 3 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

6: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

7: acetic acid / 4 h / Reflux

8: potassium carbonate / acetone / 4 h / Reflux

9: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogenchloride; dmap; sodium azide; sulfuric acid; water; hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;