(4S)-4-benzyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-1,3-oxazolidin-2-one

Base Information

• Chemical Name: (4S)-4-benzyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-1,3-oxazolidin-2-one
• CAS No.: 852148-48-2
• Molecular Formula: C₂₁H₂₀FNO₄
• Molecular Weight: 369.393
• Mol file: 852148-48-2.mol

Synonyms:(4S)-4-benzyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-1,3-oxazolidin-2-one

Chemical Property of (4S)-4-benzyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-1,3-oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-4-benzyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-1,3-oxazolidin-2-one

There total 6 articles about (4S)-4-benzyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(S)-4-Benzyl-2-oxazolidinone (90719-32-7) + 5-(4-fluorophenyl)-5-oxopentanoic acid (149437-76-3) → (4S)-4-benzyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-1,3-oxazolidin-2-one (852148-48-2)

Guidance literature:

5-(4-fluorophenyl)-5-oxopentanoic acid; With pivaloyl chloride; triethylamine; In tetrahydrofuran; at -5 - 20 ℃; for 1.5h;

(S)-4-Benzyl-2-oxazolidinone; With dmap; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 20h;

Reference yield: 78.0%

(S)-4-Benzyl-2-oxazolidinone (90719-32-7) + 5-(4-fluorophenyl)-5-oxopentanoic acid (149437-76-3) → (4S)-4-benzyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-1,3-oxazolidin-2-one (852148-48-2) + 6-(4-fluorophenyl)-3,4-dihydro-2H-pyran-2-one (914777-32-5) + 1,9-bis(4-fluorophenyl)nonane-1,5,9-trione (914777-33-6)

Guidance literature:

5-(4-fluorophenyl)-5-oxopentanoic acid; With dmap; pivaloyl chloride; In N,N-dimethyl-formamide; at 6 - 20 ℃; for 3.28333h;

(S)-4-Benzyl-2-oxazolidinone; In N,N-dimethyl-formamide; at 27 ℃; for 3.3h;

Reference yield: 78.0%

(S)-5-benzyloxazolidin-2-one (183072-04-0) + pivaloyl chloride (3282-30-2) + 5-(4-fluorophenyl)-5-oxopentanoic acid (149437-76-3) → (4S)-4-benzyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-1,3-oxazolidin-2-one (852148-48-2) + 6-(4-fluorophenyl)-3,4-dihydro-2H-pyran-2-one (914777-32-5) + 1,9-bis(4-fluorophenyl)nonane-1,5,9-trione (914777-33-6)

Guidance literature:

pivaloyl chloride; 5-(4-fluorophenyl)-5-oxopentanoic acid; With dmap; In N,N-dimethyl-formamide; at 6 - 20 ℃; for 3.28333h;

(S)-5-benzyloxazolidin-2-one; With dmap; In N,N-dimethyl-formamide; at 27 ℃; for 3.3h;

upstream raw materials:

C₁₆H₁₉FO₄

(S)-4-Benzyl-2-oxazolidinone

(S)-5-benzyloxazolidin-2-one

pivaloyl chloride

Downstream raw materials:

(4S)-4-benzyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one

(1S,9S)-1,9-bis(4-fluorophenyl)nonane-1,5,9-triol

(3R,4S)-4-(4-bromo-2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-1-phenylazetidin-2-one

(3R,4S)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-[2-{[tert-butyl(dimethyl)silyl]oxy}-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-phenylazetidin-2-one