1,2-dihydro-2-p-toluenesulfonimido-5-benzoyl-N-(1-phenylcarbamoylmethyl)pyridine

Base Information

Chemical Name:1,2-dihydro-2-p-toluenesulfonimido-5-benzoyl-N-(1-phenylcarbamoylmethyl)pyridine
CAS No.:220259-84-7
Molecular Formula:C₂₇H₂₃N₃O₄S
Molecular Weight:485.563
Hs Code.:

Synonyms:1,2-dihydro-2-p-toluenesulfonimido-5-benzoyl-N-(1-phenylcarbamoylmethyl)pyridine

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Chemical Property of 1,2-dihydro-2-p-toluenesulfonimido-5-benzoyl-N-(1-phenylcarbamoylmethyl)pyridine

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Technology Process of 1,2-dihydro-2-p-toluenesulfonimido-5-benzoyl-N-(1-phenylcarbamoylmethyl)pyridine

There total 7 articles about 1,2-dihydro-2-p-toluenesulfonimido-5-benzoyl-N-(1-phenylcarbamoylmethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 19078-71-8
2-bromo-2-phenylethanamide

: 220259-66-5
1,2-dihydro-2-(p-toluenesulfonimido)-5-benzoylpyridine

: 220259-84-7
1,2-dihydro-2-p-toluenesulfonimido-5-benzoyl-N-(1-phenylcarbamoylmethyl)pyridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;
DOI:10.1021/jm9810405

Reference yield:

: 103-82-2
phenylacetic acid

: 220259-84-7
1,2-dihydro-2-p-toluenesulfonimido-5-benzoyl-N-(1-phenylcarbamoylmethyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 5 h / Heating; Irradiation

2: oxalyl chloride / CH₂Cl₂; dimethylformamide / 3 h

3: NH₃ (gas) / toluene; hexane / 1 h

4: 96 percent / DIPEA / dimethylformamide / 24 h

With N-Bromosuccinimide; Perbenzoic acid; oxalyl dichloride; ammonia; N-ethyl-N,N-diisopropylamine; In tetrachloromethane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9810405

Reference yield:

: 58757-38-3
6-Chloronicotinoyl chloride

: 220259-84-7
1,2-dihydro-2-p-toluenesulfonimido-5-benzoyl-N-(1-phenylcarbamoylmethyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / AlCl₃ / Heating

2: 85 percent / NH₃ / ethanol / 16 h / 145 °C

3: 91 percent / pyridine / 80 - 90 °C

4: 96 percent / DIPEA / dimethylformamide / 24 h

With pyridine; aluminium trichloride; ammonia; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9810405