(R)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)piperidine-3-carboxamide

Base Information

• Chemical Name: (R)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)piperidine-3-carboxamide
• CAS No.: 1595144-50-5
• Molecular Formula: C₂₀H₁₉ClF₃N₅O
• Molecular Weight: 437.852

Synonyms:(R)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)piperidine-3-carboxamide

Chemical Property of (R)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)piperidine-3-carboxamide

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Technology Process of (R)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)piperidine-3-carboxamide

There total 6 articles about (R)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)piperidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(R)-N-(4-cyanophenylethyl)piperidine-3-carboxamide (1595144-12-9) + 4,6-dichloro-2-(trifluoromethyl)pyrimidine (705-24-8) → (R)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)piperidine-3-carboxamide (1595144-50-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 25 ℃; for 0.5h;

DOI:10.1021/jm401731q

Reference yield: 39.0%

→ (R)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)piperidine-3-carboxamide (1595144-50-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Microwave irradiation;

Reference yield:

C15H19N3O*ClH (1595144-10-7) + 4,6-dichloro-2-(trifluoromethyl)pyrimidine (705-24-8) → (R)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)piperidine-3-carboxamide (1595144-50-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 0 - 25 ℃; for 0.25h;

DOI:10.1021/jm401731q

upstream raw materials:

(R)-tert-butyl 3-((4-cyanophenylethyl)carbamoyl)piperidine-1-carboxylate

C₁₅H₁₉N₃O*ClH

4,6-dichloro-2-(trifluoromethyl)pyrimidine

(R)-1-Boc-nipecotic acid

Downstream raw materials:

(R)-N-(4-cyanophenylethyl)-1-(6-(piperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)piperidine-3-carboxamide hydrochloride

(R)-N-(4-cyanophenylethyl)-1-(2-trifluoromethyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)piperidine-3-carboxamide

1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}-4-methylpiperidine-4-carboxylic acid

1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid

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