(S)-2-Acetylamino-3-[4-(6-tert-butoxycarbonylamino-hexyloxy)-phenyl]-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-Acetylamino-3-[4-(6-tert-butoxycarbonylamino-hexyloxy)-phenyl]-propionic acid methyl ester
CAS No.:142356-18-1
Molecular Formula:C₂₃H₃₆N₂O₆
Molecular Weight:436.549
Hs Code.:

Synonyms:(S)-2-Acetylamino-3-[4-(6-tert-butoxycarbonylamino-hexyloxy)-phenyl]-propionic acid methyl ester

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Chemical Property of (S)-2-Acetylamino-3-[4-(6-tert-butoxycarbonylamino-hexyloxy)-phenyl]-propionic acid methyl ester

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Technology Process of (S)-2-Acetylamino-3-[4-(6-tert-butoxycarbonylamino-hexyloxy)-phenyl]-propionic acid methyl ester

There total 6 articles about (S)-2-Acetylamino-3-[4-(6-tert-butoxycarbonylamino-hexyloxy)-phenyl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 75-36-5
acetyl chloride

: 142356-09-0
methyl 2-(S)-amino-3-<4-<<6-amino>hexyl>oxy>phenyl>propionate

: 142356-18-1
(S)-2-Acetylamino-3-[4-(6-tert-butoxycarbonylamino-hexyloxy)-phenyl]-propionic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; In ethyl acetate; for 18h; Ambient temperature;
DOI:10.1021/jm00042a007

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 142356-18-1
(S)-2-Acetylamino-3-[4-(6-tert-butoxycarbonylamino-hexyloxy)-phenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: BH₃ / tetrahydrofuran / 1 h

2: Ph₃P, CBr₄ / tetrahydrofuran; acetonitrile / 24 h

3: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 24 h

4: 100 percent / Cs₂CO₃ / dimethylformamide / 18 h

5: H₂ / 10percent Pd/C / ethanol / 12 h

6: 95 percent / NaHCO₃ / ethyl acetate / 18 h / Ambient temperature

With carbon tetrabromide; borane; hydrogen; sodium hydride; sodium hydrogencarbonate; caesium carbonate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00042a007

Reference yield:

: 75937-12-1
6-(Boc-amino)-1-hexanol

: 142356-18-1
(S)-2-Acetylamino-3-[4-(6-tert-butoxycarbonylamino-hexyloxy)-phenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Ph₃P, CBr₄ / tetrahydrofuran; acetonitrile / 24 h

2: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 24 h

3: 100 percent / Cs₂CO₃ / dimethylformamide / 18 h

4: H₂ / 10percent Pd/C / ethanol / 12 h

5: 95 percent / NaHCO₃ / ethyl acetate / 18 h / Ambient temperature

With carbon tetrabromide; hydrogen; sodium hydride; sodium hydrogencarbonate; caesium carbonate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00042a007