acetylseryl-(O-tert-butyl)-phenylselenocysteinylalanine-N-methyl amide

Base Information

• Chemical Name: acetylseryl-(O-tert-butyl)-phenylselenocysteinylalanine-N-methyl amide
• CAS No.: 660391-72-0
• Molecular Formula: C₂₂H₃₄N₄O₅Se
• Molecular Weight: 513.496
• Mol file: 660391-72-0.mol

Synonyms:acetylseryl-(O-tert-butyl)-phenylselenocysteinylalanine-N-methyl amide

Chemical Property of acetylseryl-(O-tert-butyl)-phenylselenocysteinylalanine-N-methyl amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetylseryl-(O-tert-butyl)-phenylselenocysteinylalanine-N-methyl amide

There total 3 articles about acetylseryl-(O-tert-butyl)-phenylselenocysteinylalanine-N-methyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-acetyl-L-serine tert-butyl ether (77285-09-7) + phenylselenocysteinylalanine-N-methyl amide (660391-71-9) → acetylseryl-(O-tert-butyl)-phenylselenocysteinylalanine-N-methyl amide (660391-72-0)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In chloroform; at 23 ℃; for 6h;

DOI:10.1002/chem.200305290

Reference yield:

N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine (312746-41-1) → acetylseryl-(O-tert-butyl)-phenylselenocysteinylalanine-N-methyl amide (660391-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / DIPEA; BOP / CHCl₃ / 24 h / 23 °C

2: 75 percent / piperidine / CH₂Cl₂ / 1.5 h / 23 °C

3: 97 percent / DIPEA; BOP / CHCl₃ / 6 h / 23 °C

With piperidine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; chloroform;

DOI:10.1002/chem.200305290

Reference yield:

Fmoc-phenylselenocysteinylalanine-N-methyl amide (660391-70-8) → acetylseryl-(O-tert-butyl)-phenylselenocysteinylalanine-N-methyl amide (660391-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / piperidine / CH₂Cl₂ / 1.5 h / 23 °C

2: 97 percent / DIPEA; BOP / CHCl₃ / 6 h / 23 °C

With piperidine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; chloroform;

DOI:10.1002/chem.200305290

upstream raw materials:

N-acetyl-L-serine tert-butyl ether

phenylselenocysteinylalanine-N-methyl amide

N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine

Fmoc-phenylselenocysteinylalanine-N-methyl amide