Fmoc-phenylselenocysteinylalanine-N-methyl amide

Base Information

• Chemical Name: Fmoc-phenylselenocysteinylalanine-N-methyl amide
• CAS No.: 660391-70-8
• Molecular Formula: C₂₈H₂₉N₃O₄Se
• Molecular Weight: 550.516
• Mol file: 660391-70-8.mol

Synonyms:Fmoc-phenylselenocysteinylalanine-N-methyl amide

Chemical Property of Fmoc-phenylselenocysteinylalanine-N-methyl amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fmoc-phenylselenocysteinylalanine-N-methyl amide

There total 1 articles about Fmoc-phenylselenocysteinylalanine-N-methyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

L-alanine-N-methylamide hydrochloride (61275-22-7) + N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine (312746-41-1) → Fmoc-phenylselenocysteinylalanine-N-methyl amide (660391-70-8)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In chloroform; at 23 ℃; for 24h;

DOI:10.1002/chem.200305290

Reference yield: 75.0%

Fmoc-phenylselenocysteinylalanine-N-methyl amide (660391-70-8) → phenylselenocysteinylalanine-N-methyl amide (660391-71-9)

Guidance literature:

With piperidine; In dichloromethane; at 23 ℃; for 1.5h;

DOI:10.1002/chem.200305290

Reference yield:

Fmoc-phenylselenocysteinylalanine-N-methyl amide (660391-70-8) → acetylserylphenylselenocysteinylalanine-N-methyl amide

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / piperidine / CH₂Cl₂ / 1.5 h / 23 °C

2: 97 percent / DIPEA; BOP / CHCl₃ / 6 h / 23 °C

3: trifluoroacetic acid / 11.5 h / 0 °C

With piperidine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; chloroform;

DOI:10.1002/chem.200305290

upstream raw materials:

L-alanine-N-methylamide hydrochloride

N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine

Downstream raw materials:

phenylselenocysteinylalanine-N-methyl amide

acetylseryl-(O-tert-butyl)-phenylselenocysteinylalanine-N-methyl amide