4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione

Base Information

• Chemical Name: 4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione
• CAS No.: 60813-44-7
• Molecular Formula: C₁₆H₁₁NO₂
• Molecular Weight: 249.269
• Mol file: 60813-44-7.mol

Synonyms:4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione

Chemical Property of 4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione

There total 6 articles about 4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzaldehyde (100-52-7) + 4H-isoquinolin-1,3-dione (4456-77-3) → 4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione (60813-44-7)

Guidance literature:

potassium fluoride on basic alumina; for 0.1h; focused microwave irradiation;

DOI:10.1080/00397919808004421

Reference yield:

benzaldehyde (100-52-7) + 4H-isoquinolin-1,3-dione (4456-77-3) → 4-benzylideneisoquinoline-1,3(2H,4H)-dione + 4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione (60813-44-7)

Guidance literature:

4H-isoquinolin-1,3-dione; With piperidine; In ethanol; benzene; at 20 ℃; for 0.166667h;

benzaldehyde; In ethanol; benzene; at 85 ℃; for 2h; Sealed tube;

DOI:10.1007/s00044-020-02662-w

Reference yield:

Homophthalic acid (89-51-0) → 4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione (60813-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / aq. ammonia

2: 82 percent / KF-Al₂O₃ / 0.1 h / focused microwave irradiation

With ammonium hydroxide; potassium fluoride on basic alumina; 1: Condensation / 2: Condensation;

DOI:10.1080/00397919808004421

upstream raw materials:

benzaldehyde

4H-isoquinolin-1,3-dione

Homophthalic acid

Downstream raw materials:

benzaldehyde