4456-77-3

Basic information

• Product Name: 1,2,3,4-Tetrahydroisoquinoline-1,3-dione
• Synonyms: 1,2,3,4-Tetrahydroisoquinoline-1,3-dione;1,3-[2H,4H]-Isoquinolinedione;4H-Isoquinoline-1,3-dione;Isoquinoline-1,3(2H,4H)-dione, >=98%;2,4-dihydroisoquinoline-1,3-dione;FR 038470;NSC 409146;2H,4H-1,3-Isoquinolinedione
• CAS NO: 4456-77-3
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.15738
• EINECS: 1533716-785-6
• Mol File: 4456-77-3.mol
• Article Data: 33

Chemical Properties

• Melting Point: 223 °C
• Boiling Point: 377.148 °C at 760 mmHg
• Flash Point: 183.887 °C
• Appearance: /
• Density: 1.286 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.25±0.20(Predicted)
• CAS DataBase Reference: 1,2,3,4-Tetrahydroisoquinoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydroisoquinoline-1,3-dione(4456-77-3)
• EPA Substance Registry System: 1,2,3,4-Tetrahydroisoquinoline-1,3-dione(4456-77-3)

Safety Data

• Hazardous Substances Data: 4456-77-3(Hazardous Substances Data)

Usage

General Description

1,2,3,4-Tetrahydroisoquinoline-1,3-dione, also known as tetrahydroisoquinoline-1,3-dione, is a chemical compound with the molecular formula C9H9NO2. It is a heterocyclic compound with a bicyclic structure containing a four-membered ring fused to a six-membered ring. 1,2,3,4-Tetrahydroisoquinoline-1,3-dione has been studied for its potential pharmacological and therapeutic properties, as it exhibits antioxidant and anti-inflammatory activities. It has also been investigated for its potential use in the development of new pharmaceutical drugs. Additionally, 1,2,3,4-Tetrahydroisoquinoline-1,3-dione has been reported as an intermediate in the synthesis of other organic compounds.

InChI:InChI=1/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)9(12)10-8/h1-4H,5H2,(H,10,11,12)

Upstream product

• 89-51-0 Homophthalic acid 
• 76746-89-9 ethyl 3-methyl-1-oxo-1H-isochromene-4-carboxylate 
• 29241-85-8 1-hydroxyimino-3-oxo-1,2,3,4-tetrahydroisoquinoline 
• 95-50-1 1,2-dichloro-benzene 
• 201230-82-2 carbon monoxide 
• 195456-43-0 2-(2-iodophenyl)-acetamide 
• 925672-89-5 5-bromo-2-(cyanomethyl)benzonitrile 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 1033330-27-6 7-bromoisoquinoline-1,3(2H,4H)-dione 
• 25113-15-9 methyl 3-methyl-1-oxo-1H-isochromene-4-carboxylate 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 103-82-2 phenylacetic acid 
• 1118-02-1 trimethylsilyl isocyanate 
• 57-13-6 urea 

Downstream Products

• 38209-13-1 1-hydroxy-2-phenyl-5H-pyrano[2,3-c]isoquinoline-3,6-dione 
• 38324-88-8 2-benzyl-1-hydroxy-5H-pyrano[2,3-c]isoquinoline-3,6-dione 
• 59168-22-8 N-<2-(3,4-dimethoxyphenyl)ethyl>homophthalimide 
• 40073-36-7 1-amino-3-bromoisoquinoline 
• 60813-44-7 4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione 
• 101438-87-3 4-(1,3-dioxo-2,3-dihydro-1H-[4]isochinolyLiDenemethyl)-benzonitrile 
• 150688-56-5 4-(4-methoxybenzylidene)isoquinoline-1,3(2H,4H)-dione 

Relevant articles and documents

4-benzylideneisoquinoline-1,3(2H,4H)-diones as tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors

Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase II (Top2) mediated DNA damages, including double-strand breaks (DSBs) that underpin the anticancer mechanism of clinical Top2 poisons such as etoposide (ETP). Inhibition of TDP2 could sensitize

Enantioselective synthesis of isoquinoline-1,3(2: H,4 H)-dione derivatives via a chiral phosphoric acid catalyzed aza-Friedel-Crafts reaction

A highly enantioselective aza-Friedel-Crafts reaction of structurally new ketimines with indoles and pyrrole is developed by using a chiral phosphoric acid as the catalyst. This protocol enables the first enantioselective synthesis of isoquinoline-1,3(2H,

Superelectrophiles in Synthesis: Preparation of Aromatic Imides

Aromatic carboxylic acids are found to undergo reactions with isocyanates, wherein triflic acid promotes the formation of aromatic imide products in fair to good yields. It is proposed that the carboxylic acid group directs the isocyanate electrophile to