2-(Pyridin-3-yl)acetamide

Base Information

• Chemical Name: 2-(Pyridin-3-yl)acetamide
• CAS No.: 3724-16-1
• Molecular Formula: C7H8 N2 O
• Molecular Weight: 136.153
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40340452
• Nikkaji Number: J647.205B
• Wikidata: Q82110098
• Mol file: 3724-16-1.mol

Synonyms:2-(pyridin-3-yl)acetamide;3724-16-1;3-Pyridineacetamide;2-pyridin-3-ylacetamide;2-(3-Pyridyl)acetamide;pyridine-3-acetamide;2-Pyridylacetamide;3-Pyridylacetamide;beta-Pyridylethanamide;2-(pyridine-3-yl)-acetamide;3-pyridylacetamide;2-(3-Pyridinyl)acetamide;2-(3-Pyridinyl)acetamide #;SCHEMBL794394;3-(aminocarbonylmethyl)pyridine;DTXSID40340452;MFCD08236789;-Pyridylethanamide;AKOS006342681;AM85743;DS-16245;CS-0008758;FT-0756840;EN300-95711;F30204

Chemical Property of 2-(Pyridin-3-yl)acetamide

Chemical Property:

• Vapor Pressure: 2.25E-05mmHg at 25°C
• Melting Point: 122-124°C
• Refractive Index: 1.557
• Boiling Point: 360.3°C at 760 mmHg
• Flash Point: 171.7°C
• PSA: 55.98000
• Density: 1.17
• LogP: 0.80970
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 125

Purity/Quality:

97% ^*data from raw suppliers

2-(Pyridin-3-yl)acetamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CN=C1)CC(=O)N

Technology Process of 2-(Pyridin-3-yl)acetamide

There total 7 articles about 2-(Pyridin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-pyridinylacetonitrile (6443-85-2) → 2-(pyridin-3-yl)acetamide (3724-16-1)

Guidance literature:

With Os(hydride)6(triisopropylphosphine)2; water; In tetrahydrofuran-d8; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.inorgchem.1c00380

Reference yield: 76.0%

methyl pyridine-3-acetate (39998-25-9) → 2-(pyridin-3-yl)acetamide (3724-16-1)

Guidance literature:

With ammonium hydroxide; In water; at 20 ℃;

Reference yield:

pyridyl-3-yl-acetic acid (501-81-5) → 2-(pyridin-3-yl)acetamide (3724-16-1)

Guidance literature:

With ammonia; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2008.02.059

upstream raw materials:

methyl-3-pyridylketone

methyl pyridine-3-acetate

pyridin-3-yl-acetic acid ethyl ester

pyridyl-3-yl-acetic acid

Downstream raw materials:

3-pyridinylacetonitrile

pyridine-3-carbonitrile

1-(pyridin-3-yl)-2-propanone

(+/-)-1-(3-pyridyl)propan-2-amine