4-(chloromethyl)-8-methyl-2-oxo-2H-chromen-7-yl 4-cyanobenzenesulfonate

Base Information

• Chemical Name: 4-(chloromethyl)-8-methyl-2-oxo-2H-chromen-7-yl 4-cyanobenzenesulfonate
• CAS No.: 1427203-73-3
• Molecular Formula: C₁₈H₁₂ClNO₅S
• Molecular Weight: 389.816
• Mol file: 1427203-73-3.mol

Synonyms:4-(chloromethyl)-8-methyl-2-oxo-2H-chromen-7-yl 4-cyanobenzenesulfonate

Chemical Property of 4-(chloromethyl)-8-methyl-2-oxo-2H-chromen-7-yl 4-cyanobenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(chloromethyl)-8-methyl-2-oxo-2H-chromen-7-yl 4-cyanobenzenesulfonate

There total 2 articles about 4-(chloromethyl)-8-methyl-2-oxo-2H-chromen-7-yl 4-cyanobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(chloromethyl)-7-hydroxy-8-methyl-2H-chromen-2-one (163684-50-2) + p-cyanobenzenesulfonyl chloride (49584-26-1) → 4-(chloromethyl)-8-methyl-2-oxo-2H-chromen-7-yl 4-cyanobenzenesulfonate (1427203-73-3)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1021/jm4000769

Reference yield:

2-methylbenzene-1,3-diol (608-25-3) → 4-(chloromethyl)-8-methyl-2-oxo-2H-chromen-7-yl 4-cyanobenzenesulfonate (1427203-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 24 h / 0 - 20 °C

2: triethylamine / acetonitrile / 18 h / 20 °C

With sulfuric acid; triethylamine; In acetonitrile;

DOI:10.1021/jm4000769

Reference yield: 90.0%

4-(chloromethyl)-8-methyl-2-oxo-2H-chromen-7-yl 4-cyanobenzenesulfonate (1427203-73-3) + methylamine (74-89-5) → C19H16N2O5S (1427203-90-4)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/jm4000769

upstream raw materials:

4-(chloromethyl)-7-hydroxy-8-methyl-2H-chromen-2-one

p-cyanobenzenesulfonyl chloride

2-methylbenzene-1,3-diol

Downstream raw materials:

C₁₉H₁₆N₂O₅S