2'-chloro-5'-(trifluoromethyl)-succinanilic acid

Base Information

• Chemical Name: 2'-chloro-5'-(trifluoromethyl)-succinanilic acid
• CAS No.: 199803-99-1
• Molecular Formula: C₁₁H₉ClF₃NO₃
• Molecular Weight: 295.646
• Mol file: 199803-99-1.mol

Synonyms:2'-chloro-5'-(trifluoromethyl)-succinanilic acid

Chemical Property of 2'-chloro-5'-(trifluoromethyl)-succinanilic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-chloro-5'-(trifluoromethyl)-succinanilic acid

There total 1 articles about 2'-chloro-5'-(trifluoromethyl)-succinanilic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

succinic acid anhydride (108-30-5) + 3-amino-4-chlorobenzotrifluoride (121-50-6) → 2'-chloro-5'-(trifluoromethyl)-succinanilic acid (199803-99-1)

Guidance literature:

In toluene; for 2.5h; Reflux;

DOI:10.1016/j.biopha.2019.108747

Reference yield: 75.2%

shikonin (517-88-4,517-89-5,11031-58-6,54952-43-1,85921-41-1) + 2'-chloro-5'-(trifluoromethyl)-succinanilic acid (199803-99-1) → 1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl 4-(2-chloro-5-(trifluoromethyl)phenylamino)-4-oxobutanoate

Guidance literature:

2'-chloro-5'-(trifluoromethyl)-succinanilic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 0.25h; Cooling with ice;

shikonin; In dichloromethane; at 20 ℃; for 6h; Cooling with ice;

DOI:10.1016/j.biopha.2019.108747

upstream raw materials:

succinic acid anhydride

3-amino-4-chlorobenzotrifluoride