N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-methyl-2-cyclohexyl-2-hydroxy-2-phenylacetamide

Base Information

Chemical Name:N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-methyl-2-cyclohexyl-2-hydroxy-2-phenylacetamide
CAS No.:131839-63-9
Molecular Formula:C₂₇H₃₄N₂O₂
Molecular Weight:418.579
Hs Code.:

Synonyms:N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-methyl-2-cyclohexyl-2-hydroxy-2-phenylacetamide

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Chemical Property of N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-methyl-2-cyclohexyl-2-hydroxy-2-phenylacetamide

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Technology Process of N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-methyl-2-cyclohexyl-2-hydroxy-2-phenylacetamide

There total 8 articles about N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-methyl-2-cyclohexyl-2-hydroxy-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027058-72-5
N-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-ylmethyl)-2-chloro-2-cyclohexyl-2-phenyl-acetamide

: 131839-63-9
N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-methyl-2-cyclohexyl-2-hydroxy-2-phenylacetamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 90 ℃; for 1h;
DOI:10.1248/cpb.42.74

Reference yield:

: 92298-22-1
2-chloro-2-cyclohexyl-2-phenylacetyl chloride

: 131839-63-9
N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-methyl-2-cyclohexyl-2-hydroxy-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: CHCl₃ / 4.5 h / 0 - 20 °C

2: aq. HCl / dioxane / 1 h / 90 °C

With hydrogenchloride; In 1,4-dioxane; chloroform;
DOI:10.1248/cpb.42.74

Reference yield:

: 100-39-0
benzyl bromide

: 131839-63-9
N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-methyl-2-cyclohexyl-2-hydroxy-2-phenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetone / 4 h / Heating

2: NaBH₄ / methanol / 13 h / Ambient temperature

3: 58 percent / aq. NaOH / methanol / 23 h / Heating

4: CHCl₃ / 4.5 h / 0 - 20 °C

5: aq. HCl / dioxane / 1 h / 90 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; In 1,4-dioxane; methanol; chloroform; acetone;
DOI:10.1248/cpb.42.74