2,3-dihydro-3-methoxycarbonylmethylthio-7-nitro-2-phenylmethyl-1H-isoindol-1-one

Base Information

Chemical Name:2,3-dihydro-3-methoxycarbonylmethylthio-7-nitro-2-phenylmethyl-1H-isoindol-1-one
CAS No.:332935-02-1
Molecular Formula:C₁₈H₁₆N₂O₅S
Molecular Weight:372.401
Hs Code.:

Synonyms:2,3-dihydro-3-methoxycarbonylmethylthio-7-nitro-2-phenylmethyl-1H-isoindol-1-one

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Chemical Property of 2,3-dihydro-3-methoxycarbonylmethylthio-7-nitro-2-phenylmethyl-1H-isoindol-1-one

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Technology Process of 2,3-dihydro-3-methoxycarbonylmethylthio-7-nitro-2-phenylmethyl-1H-isoindol-1-one

There total 6 articles about 2,3-dihydro-3-methoxycarbonylmethylthio-7-nitro-2-phenylmethyl-1H-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2365-48-2
Methyl thioglycolate

: 332935-12-3
2,3-dihydro-3-hydroxy-7-nitro-2-phenylmethyl-1H-isoindol-1-one

: 332935-02-1
2,3-dihydro-3-methoxycarbonylmethylthio-7-nitro-2-phenylmethyl-1H-isoindol-1-one

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃;
DOI:10.1002/jhet.5570370622

Reference yield:

: 641-70-3
3-nitrophthalic acid anhydride

: 332935-02-1
2,3-dihydro-3-methoxycarbonylmethylthio-7-nitro-2-phenylmethyl-1H-isoindol-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / Et₃N / 3 h / Heating

2: NaBH₄; ethanolic HCl / methanol

3: 78 percent / p-TSA / CH₂Cl₂ / 20 °C

With hydrogenchloride; sodium tetrahydroborate; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1002/jhet.5570370622

Reference yield:

: 603-62-3
4-nitro-1H-isoindole-1,3(2H)-dione

: 332935-02-1
2,3-dihydro-3-methoxycarbonylmethylthio-7-nitro-2-phenylmethyl-1H-isoindol-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / 18-C-6; K₂CO₃; KI / toluene / 24 h / Heating

2: NaBH₄; ethanolic HCl / methanol

3: 78 percent / p-TSA / CH₂Cl₂ / 20 °C

With hydrogenchloride; sodium tetrahydroborate; 18-crown-6 ether; potassium carbonate; toluene-4-sulfonic acid; potassium iodide; In methanol; dichloromethane; toluene;
DOI:10.1002/jhet.5570370622