1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(pyridin-2-yl)-1,4-diazepane

Base Information

Chemical Name:1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(pyridin-2-yl)-1,4-diazepane
CAS No.:1373271-02-3
Molecular Formula:C₂₂H₂₉ClN₄
Molecular Weight:384.952
Hs Code.:

Synonyms:1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(pyridin-2-yl)-1,4-diazepane

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Chemical Property of 1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(pyridin-2-yl)-1,4-diazepane

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Technology Process of 1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(pyridin-2-yl)-1,4-diazepane

There total 5 articles about 1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(pyridin-2-yl)-1,4-diazepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1373273-20-1
1-(piperidin-4-yl)-4-(pyridin-2-yl)-1,4-diazepane

: 89-98-5
2-chloro-benzaldehyde

: 1373271-02-3
1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(pyridin-2-yl)-1,4-diazepane

Guidance literature:: 1-(piperidin-4-yl)-4-(pyridin-2-yl)-1,4-diazepane; 2-chloro-benzaldehyde; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 18h;

With water; sodium carbonate; In dichloromethane; at 20 ℃;

Reference yield:

: 505-66-8
1,4-Diazacycloheptane

: 1373271-02-3
1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(pyridin-2-yl)-1,4-diazepane

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.67 h / 180 - 200 °C / Microwave irradiation

2: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 109-09-1
2-chloropyridine

: 1373271-02-3
1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(pyridin-2-yl)-1,4-diazepane

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.67 h / 180 - 200 °C / Microwave irradiation

2: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;