(6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol

Base Information

Chemical Name:(6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol
CAS No.:1242597-68-7
Molecular Formula:C₁₆H₂₃NO₂
Molecular Weight:261.364
Hs Code.:

Synonyms:(6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol

Suppliers and Price of (6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol

Chemical Property:

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Technology Process of (6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol

There total 8 articles about (6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1242597-75-6
(6S,8aR)-6-(4-methoxyphenyl)hexahydroindolizin-7(1H)-one

: 917-54-4
methyllithium

: 1242597-68-7
(6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol

Guidance literature:: (6S,8aR)-6-(4-methoxyphenyl)hexahydroindolizin-7(1H)-one; methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.75h;

With methanol; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; diastereoselective reaction;
DOI:10.1021/jo101051w

Reference yield:

: 1301743-51-0
(6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)indolizin-7-ol

: 1242597-68-7
(6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

2: tetrahydrofuran; diethyl ether / 24.5 h / 0 - 20 °C

With sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/ejoc.201100125

Reference yield:

: 1301743-54-3
methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate

: 1242597-68-7
(6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / methanol; water / 0 - 20 °C

2.1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere

3.1: tetramethylammonium triacetoxyborohydride / acetic acid; acetonitrile / 1 h / 0 °C

4.1: indium; ammonium chloride / ethanol; water / 4 h / Reflux

4.2: 5 h / Reflux

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 25 h / 0 - 20 °C

6.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

7.1: tetrahydrofuran; diethyl ether / 24.5 h / 0 - 20 °C

With hydrogenchloride; indium; lithium aluminium tetrahydride; sulfur trioxide pyridine complex; ammonium chloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; tetramethylammonium triacetoxyborohydride; zinc; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1002/ejoc.201100125