methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate

Base Information

Chemical Name:methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate
CAS No.:1301743-54-3
Molecular Formula:C₁₈H₂₅NO₈
Molecular Weight:383.398
Hs Code.:

Synonyms:methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate

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Chemical Property of methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate

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Technology Process of methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate

There total 1 articles about methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67-56-1
methanol

: 1301743-47-4
(S)-7-((R)-1-(4-methoxyphenyl)-2-nitroethyl)-1,4,8-trioxaspiro[4.6]undecan-9-one

: 1301743-54-3
methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate

Guidance literature:: With potassium carbonate; at 0 - 20 ℃; for 0.5h;
DOI:10.1002/ejoc.201100125

Reference yield: 95.0%

: 1301743-54-3
methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate

: 1301743-48-5
(6S,7R)-methyl 6-hydroxy-7-(4-methoxyphenyl)-8-nitro-4-oxooctanoate

Guidance literature:: With hydrogenchloride; In methanol; water; at 0 - 20 ℃;
DOI:10.1002/ejoc.201100125

Reference yield:

: 1301743-54-3
methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate

: 1242597-79-0
(S)-1,2,3,5,8,8a-hexahydro-7-(3,4-dimethoxyphenyl)-6-(4-methoxyphenyl)indolizine

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / methanol; water / 0 - 20 °C

2.1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere

3.1: tetramethylammonium triacetoxyborohydride / acetic acid; acetonitrile / 1 h / 0 °C

4.1: indium; ammonium chloride / ethanol; water / 4 h / Reflux

4.2: 5 h / Reflux

5.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

6.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

6.2: 1 h / 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 85 °C / Inert atmosphere

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 25 h / 0 - 20 °C

With hydrogenchloride; indium; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfur trioxide pyridine complex; potassium hydride; sodium carbonate; ammonium chloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; tetramethylammonium triacetoxyborohydride; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid; acetonitrile; 7.1: Suzuki coupling;
DOI:10.1002/ejoc.201100125