N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Base Information

Chemical Name:N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide
CAS No.:500775-96-2
Molecular Formula:C₃₅H₃₇N₅O₆S
Molecular Weight:655.775
Hs Code.:

<i>N</i>-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1<i>H</i>-purin-2-yl)-isobutyramide

Synonyms:N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

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Chemical Property of N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

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Technology Process of N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

There total 3 articles about N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 263746-51-6
4,4'-dimethoxytriphenylmethanethiol

: 500775-91-7
Methanesulfonic acid (2R,3S,5R)-3-hydroxy-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester

: 500775-96-2
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: With N,N,N',N'-tetramethylguanidine; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1081/NCN-120023015

Reference yield:

: 40615-35-8
4,4'-dimethoxytrityl alcohol

: 500775-96-2
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / H₂S; CHCl₂COOH / CH₂Cl₂ / 1.25 h

2: 45 percent / 1,1,3,3-tetramethylguanidine / dimethylsulfoxide / 3 h / 20 °C

With dichloro-acetic acid; hydrogen sulfide; N,N,N',N'-tetramethylguanidine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/hlca.200490252

Reference yield:

: 68892-42-2
N-isobutyryl-2'-deoxyguanosine

: 500775-96-2
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / 1,1,3,3-tetramethylguanidine / dimethylsulfoxide / 3 h / 20 °C

With N,N,N',N'-tetramethylguanidine; In dimethyl sulfoxide;
DOI:10.1002/hlca.200490252