4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester

Base Information

Chemical Name:4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester
CAS No.:201608-24-4
Molecular Formula:C₂₅H₃₀N₂O₄
Molecular Weight:422.524
Hs Code.:

Synonyms:4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester

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Chemical Property of 4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester

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Technology Process of 4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester

There total 11 articles about 4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 201608-21-1
Trifluoro-methanesulfonic acid 4-((2R,4S)-3-benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-phenyl ester

: 201608-24-4
4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; at 70 ℃; for 3h; under 760 Torr;
DOI:10.1039/a704704e

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 201608-24-4
4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

2: HCl / Ambient temperature

3: methanol; ethanol / 30 h / Ambient temperature

4: pentane / 3 h / Heating

5: 1.) HCl, 2.) Et₃N / 1.) MeOH, 3 h, r.t.; 2.) Ch₂Cl₂, 6 h, r.t.

6: 92 percent / LDA / tetrahydrofuran / 1.) 1 h, 2.) 2 h

7: H₂ / Pd/C / methanol / 3 h

8: 2,6-lutidine, DMAP / CH₂Cl₂ / 2 h / -30 °C

9: 97 percent / 1,3-bis(diphenylphosphino)propane, Et₃N / Pd(OAc)2 / 3 h / 70 °C / 760 Torr

With 2,6-dimethylpyridine; hydrogenchloride; dmap; 1,3-bis-(diphenylphosphino)propane; hydrogen; triethylamine; lithium diisopropyl amide; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; pentane;
DOI:10.1039/a704704e

Reference yield:

: 69489-40-3
D-2-[p-(benzyloxy)phenyl]glycine

: 201608-24-4
4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: HCl / Ambient temperature

2: methanol; ethanol / 30 h / Ambient temperature

3: pentane / 3 h / Heating

4: 1.) HCl, 2.) Et₃N / 1.) MeOH, 3 h, r.t.; 2.) Ch₂Cl₂, 6 h, r.t.

5: 92 percent / LDA / tetrahydrofuran / 1.) 1 h, 2.) 2 h

6: H₂ / Pd/C / methanol / 3 h

7: 2,6-lutidine, DMAP / CH₂Cl₂ / 2 h / -30 °C

8: 97 percent / 1,3-bis(diphenylphosphino)propane, Et₃N / Pd(OAc)2 / 3 h / 70 °C / 760 Torr

With 2,6-dimethylpyridine; hydrogenchloride; dmap; 1,3-bis-(diphenylphosphino)propane; hydrogen; triethylamine; lithium diisopropyl amide; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; pentane;
DOI:10.1039/a704704e