(2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile

Base Information

• Chemical Name: (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile
• CAS No.: 461440-76-6
• Molecular Formula: C₁₁H₁₁F₃N₂O
• Molecular Weight: 244.216
• Mol file: 461440-76-6.mol

Synonyms:(2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile

Chemical Property of (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile

There total 2 articles about (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

trimethylsilyl cyanide (7677-24-9) + (4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine (1044222-31-2) → (2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile + (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile (461440-76-6)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo0607717

Reference yield:

D-2-phenylglycinol (56613-80-0) → (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile (461440-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: PPTS / toluene

2: BF₃*OEt₂ / 12 h / -78 - 20 °C

With boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; In toluene;

DOI:10.1016/S0040-4039(02)00330-1

Reference yield: 80.0%

(2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile (461440-76-6) → (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propylamine (911411-84-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 24h;

DOI:10.1021/jo0607717

upstream raw materials:

trimethylsilyl cyanide

(4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

D-2-phenylglycinol

Downstream raw materials:

(2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propylamine