4-(cyclopropoxy)-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide

Base Information

Chemical Name:4-(cyclopropoxy)-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide
CAS No.:1310817-16-3
Molecular Formula:C₂₆H₂₆N₄O₃
Molecular Weight:442.517
Hs Code.:

Synonyms:4-(cyclopropoxy)-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide

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Chemical Property of 4-(cyclopropoxy)-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide

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Technology Process of 4-(cyclopropoxy)-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide

There total 14 articles about 4-(cyclopropoxy)-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1310817-01-6
5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-amine

: 1310817-14-1
1-[[4-(cyclopropoxy)benzoyl]amino]cyclopropanecarboxylic acid

: 1310817-16-3
4-(cyclopropoxy)-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 15115-58-9
3-(2-bromophenyl)propionic acid

: 1310817-16-3
4-(cyclopropoxy)-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 80 - 85 °C / Industry scale; Inert atmosphere

1.2: 20 - 125 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / 25 - 40 °C / Reflux

2.2: pH 8

3.1: n-butyllithium; diisopropylamine / 2-MeTHF; hexane / -80 - -70 °C / Industry scale

3.2: pH 7.5

4.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 h / 60 - 70 °C / Inert atmosphere; Industry scale

5.1: hydrogen; sodium hydroxide / Raney nickel / methanol / 40 h / 60 - 65 °C / 2999.54 - 3361.55 Torr

6.1: ammonium hydroxide / water / 25 °C / pH 9 / Industry scale

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C

With ammonium hydroxide; n-butyllithium; thionyl chloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; sodium hydroxide; Raney nickel; In methanol; 2-MeTHF; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1005-61-4
4-bromophenyl vinyl ether

: 1310817-16-3
4-(cyclopropoxy)-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethylzinc / n-heptane; 1,2-dichloro-ethane / 3 h / 0 - 5 °C

2.1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane; ethyl acetate / 0.33 h / -78 - -70 °C

2.2: 0.67 h / -78 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 °C

4.1: triethylamine / dichloromethane / 16 h / 20 °C

5.1: ethanol; sodium hydroxide / 3 h / 65 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C

With n-butyllithium; oxalyl dichloride; ethanol; diethylzinc; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; hexane; n-heptane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;