ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate

Base Information

• Chemical Name: ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate
• CAS No.: 897372-42-8
• Molecular Formula: C₁₇H₂₃N₃O₂
• Molecular Weight: 301.389
• Mol file: 897372-42-8.mol

Synonyms:ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate

Chemical Property of ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate

There total 3 articles about ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethoxycarbonylmethylphenylhydrazine (897373-28-3) + trimethylacetylacetonitrile (59997-51-2) → ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate (897372-42-8)

Guidance literature:

With hydrogenchloride; In ethanol; water; Heating / reflux;

Reference yield:

ethanol (64-17-5) + trimethylacetylacetonitrile (59997-51-2) + 2-(3-(carboxymethyl)phenyl)hydrazinium chloride (1357621-00-1) → ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate (897372-42-8)

Guidance literature:

Reflux;

DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

3-amino phenylacetic acid (14338-36-4) → ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate (897372-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: Reflux

With hydrogenchloride; sodium nitrite; In water;

DOI:10.1016/j.ejmech.2011.11.019

upstream raw materials:

3-ethoxycarbonylmethylphenylhydrazine

trimethylacetylacetonitrile

ethanol

2-(3-(carboxymethyl)phenyl)hydrazinium chloride

Downstream raw materials:

[3-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-tert-butyl-1H-pyrazol-1-yl)phenyl]acetic acid

ethyl [3-(3-tert-butyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

2-[3-(3-tert-butyl-5-amino-1H-pyrazol-1-yl)phenyl]acetamide

C₂₁H₂₇N₃O₄