N-Boc-3-Methylenepiperidine

Base Information

Chemical Name:N-Boc-3-Methylenepiperidine
CAS No.:276872-89-0
Molecular Formula:C11H19 N O2
Molecular Weight:197.277
Hs Code.:2933399090
European Community (EC) Number:846-261-1
DSSTox Substance ID:DTXSID40460144
Nikkaji Number:J1.681.474A
Wikidata:Q72449939
Mol file:276872-89-0.mol

Synonyms:276872-89-0;N-Boc-3-Methylenepiperidine;Tert-butyl 3-methylidenepiperidine-1-carboxylate;N-Boc-3-methylene-piperidine;1-Boc-3-methylenepiperidine;tert-butyl 3-methylenepiperidine-1-carboxylate;3-Methylene-piperidine-1-carboxylic acid tert-butyl ester;1-Boc-3-Methylene-piperidine;3-methylene-1-piperidinecarboxylic acid tert-butyl ester;1-PIPERIDINECARBOXYLIC ACID, 3-METHYLENE-, 1,1-DIMETHYLETHYL ESTER;MFCD08706141;N-Boc-3-methylene piperidine;1-Boc-3-methylene piperidine;SCHEMBL893656;SCHEMBL8251283;DTXSID40460144;CENNZHRFKNCIBU-UHFFFAOYSA-N;CS-D0759;AKOS006281156;PB10606;DS-11259;SY020981;AM20090349;BB 0259204;FT-0653369;EN300-69084;A819160;J-512901;1-Piperidinecarboxylic acid,3-methylene-,tert-butyl ester

Suppliers and Price of N-Boc-3-Methylenepiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
1-Boc-3-methylenepiperidine
250mg
$ 355.00

TRC
1-Boc-3-methylenepiperidine
1g
$ 165.00

TRC
1-Boc-3-methylenepiperidine
250mg
$ 85.00

TRC
1-Boc-3-methylenepiperidine
10g
$ 985.00

SynQuest Laboratories
N-Boc-3-Methylene-piperidine 95%
5 g
$ 750.00

Sigma-Aldrich
3-Methylene-1-piperidinecarboxylic acid tert-butyl ester
1g
$ 1060.00

J&W Pharmlab
3-Methylene-piperidine-1-carboxylicacidtert-butylester 95%
1g
$ 60.00

J&W Pharmlab
3-Methylene-piperidine-1-carboxylicacidtert-butylester 95%
5g
$ 180.00

J&W Pharmlab
3-Methylene-piperidine-1-carboxylicacidtert-butylester 95%
25g
$ 600.00

Crysdot
N-Boc-3-Methylenepiperidine 98%
10g
$ 258.00

Total 50 raw suppliers

Chemical Property of N-Boc-3-Methylenepiperidine

Chemical Property:

Vapor Pressure:0.0144mmHg at 25°C
Refractive Index:1.481
Boiling Point:257.6°C at 760 mmHg
PKA:-1.46±0.20(Predicted)
Flash Point:109.6°C
PSA：29.54000
Density:1g/cm³
LogP:2.51140
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:197.141578849
Heavy Atom Count:14
Complexity:240

Purity/Quality:

99%, ^*data from raw suppliers

1-Boc-3-methylenepiperidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCCC(=C)C1
Uses 1-Boc-3-methylenepiperidine is a reagent used in the preparation of analogs of spirocyclic quinuclidinyl-Δ2-isoxazolines as potent and selective α7 nicotinic agonists.

Technology Process of N-Boc-3-Methylenepiperidine

There total 9 articles about N-Boc-3-Methylenepiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 98977-36-7
3-oxo-piperidine-1-carboxylic acid tert-butyl ester

: 276872-89-0
tert-butyl 3-methylidenepiperidine-1-carboxylate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/acs.jmedchem.0c00450

Reference yield: 58.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 357289-94-2
N-(3-phenylselenopropyl)-2-methyleneaziridine

: 276872-89-0
tert-butyl 3-methylidenepiperidine-1-carboxylate

Guidance literature:: N-(3-phenylselenopropyl)-2-methyleneaziridine; With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 6h; Heating;

di-tert-butyl dicarbonate; With triethylamine; In benzene; at 20 ℃; Further stages.;
DOI:10.1021/ol016194k