ethyl 1,4-dihydro-2,6-dimethyl-4-<2-(trifluoromethyl)phenyl>pyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 1,4-dihydro-2,6-dimethyl-4-<2-(trifluoromethyl)phenyl>pyridine-3-carboxylate
• CAS No.: 85831-27-2
• Molecular Formula: C₁₇H₁₈F₃NO₂
• Molecular Weight: 325.331

Synonyms:ethyl 1,4-dihydro-2,6-dimethyl-4-<2-(trifluoromethyl)phenyl>pyridine-3-carboxylate

Chemical Property of ethyl 1,4-dihydro-2,6-dimethyl-4-<2-(trifluoromethyl)phenyl>pyridine-3-carboxylate

Chemical Property:

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Technology Process of ethyl 1,4-dihydro-2,6-dimethyl-4-<2-(trifluoromethyl)phenyl>pyridine-3-carboxylate

There total 2 articles about ethyl 1,4-dihydro-2,6-dimethyl-4-<2-(trifluoromethyl)phenyl>pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

4-<2-(trifluoromethyl)phenyl>-3-buten-2-one (76293-37-3) + ethyl 3-aminobut-2-enoate (626-34-6) → ethyl 1,4-dihydro-2,6-dimethyl-4-<2-(trifluoromethyl)phenyl>pyridine-3-carboxylate (85831-27-2)

Guidance literature:

In ethanol; at 170 ℃; for 24h;

DOI:10.1021/jo00284a036

Reference yield:

2-Trifluoromethylbenzaldehyde (447-61-0) → ethyl 1,4-dihydro-2,6-dimethyl-4-<2-(trifluoromethyl)phenyl>pyridine-3-carboxylate (85831-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / 10percent aq. NaOH / Ambient temperature

2: 38 percent / ethanol / 24 h / 170 °C

With sodium hydroxide; In ethanol;

DOI:10.1021/jo00284a036

Reference yield: 74.0%

ethyl chlorooximidoacetate (95080-93-6) + ethyl 1,4-dihydro-2,6-dimethyl-4-<2-(trifluoromethyl)phenyl>pyridine-3-carboxylate (85831-27-2) → diethyl (3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifuoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylate (123486-69-1,123538-37-4,123538-38-5)

Guidance literature:

With triethylamine; In diethyl ether; for 12h;

DOI:10.1021/jo00284a036

upstream raw materials:

4-<2-(trifluoromethyl)phenyl>-3-buten-2-one

ethyl 3-aminobut-2-enoate

2-Trifluoromethylbenzaldehyde

Downstream raw materials:

ethyl (3aα,4α,7aα)-3-benzoyl-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-5-carboxylate

diethyl (3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifuoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylate

ethyl (3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-3-(phenylsulfonyl)-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-5-carboxylate

ethyl (3aα,4α,7aα)-3-cyano-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-5-carboxylate

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