2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methylamide

Base Information

Chemical Name:2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methylamide
CAS No.:1026396-89-3
Molecular Formula:C₂₃H₂₈N₄O₃S₂
Molecular Weight:472.632
Hs Code.:

Synonyms:2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methylamide

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Chemical Property of 2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methylamide

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Technology Process of 2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methylamide

There total 11 articles about 2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 144629-51-6
ethyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

: 74-89-5
methylamine

: 1026396-89-3
2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methylamide

Guidance literature:: In methanol; at 80 ℃; for 60h;
DOI:10.1021/jm00013a013

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1026396-89-3
2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

2: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

3: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

4: 81 percent / conc. HCl / ethanol / 2 h / Heating

5: 91 percent / methanol / 60 h / 80 °C

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; In methanol; ethanol; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1021/jm00013a013

Reference yield:

: 92748-09-9
2-bromobenzene-1-sulfonamide

: 1026396-89-3
2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / dimethylformamide / 2 h / Ambient temperature

2: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

3: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

4: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

5: 81 percent / conc. HCl / ethanol / 2 h / Heating

6: 91 percent / methanol / 60 h / 80 °C

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; In methanol; ethanol; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1021/jm00013a013