(adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid ethyl ester

Base Information

• Chemical Name: (adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid ethyl ester
• CAS No.: 565453-30-7
• Molecular Formula: C₂₂H₂₉NO₄
• Molecular Weight: 371.477
• Mol file: 565453-30-7.mol

Synonyms:(adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid ethyl ester

Chemical Property of (adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid ethyl ester

There total 2 articles about (adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.6%

ethyl 2-(adamant-1-yl)aminoacetate (3716-68-5) + benzyl chloroformate (501-53-1,94274-21-2) → (adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid ethyl ester (565453-30-7)

Guidance literature:

With potassium carbonate; In dichloromethane; at 0 - 20 ℃; for 19.5h;

DOI:10.1021/jm030091l

Reference yield:

1-Adamantanamine (768-94-5) → (adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid ethyl ester (565453-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / K₂CO₃ / CH₂Cl₂ / 19.5 h / 0 - 20 °C

2: 73.6 percent / K₂CO₃ / CH₂Cl₂ / 19.5 h / 0 - 20 °C

With potassium carbonate; In dichloromethane;

DOI:10.1021/jm030091l

Reference yield: 92.0%

(adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid ethyl ester (565453-30-7) → (adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid (565453-31-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 50 ℃; for 22h;

DOI:10.1021/jm030091l

upstream raw materials:

ethyl 2-(adamant-1-yl)aminoacetate

benzyl chloroformate

1-Adamantanamine

Downstream raw materials:

(adamantan-1-yl-benzyloxycarbonyl-amino)-acetic acid

adamantan-1-yl-(2-azetidin-1-yl-2-oxo-ethyl)-carbamic acid benzyl ester

adamantan-1-yl-(2-oxo-2-pyrrolidin-1-yl-ethyl)-carbamic acid benzyl ester

adamantan-1-yl-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-carbamic acid benzyl ester