N¹-2-pyrimidyl-p-(benzyloxycarbonylamino)benzenesulfonamide

Base Information

• Chemical Name: N¹-2-pyrimidyl-p-(benzyloxycarbonylamino)benzenesulfonamide
• CAS No.: 288066-50-2
• Molecular Formula: C₁₈H₁₆N₄O₄S
• Molecular Weight: 384.415
• Mol file: 288066-50-2.mol

Synonyms:N¹-2-pyrimidyl-p-(benzyloxycarbonylamino)benzenesulfonamide

Chemical Property of N¹-2-pyrimidyl-p-(benzyloxycarbonylamino)benzenesulfonamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N¹-2-pyrimidyl-p-(benzyloxycarbonylamino)benzenesulfonamide

There total 1 articles about N¹-2-pyrimidyl-p-(benzyloxycarbonylamino)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

sulfadiazine (68-35-9) + benzyl chloroformate (501-53-1,94274-21-2) → N1-2-pyrimidyl-p-(benzyloxycarbonylamino)benzenesulfonamide (288066-50-2)

Guidance literature:

In pyridine; at 20 ℃; for 8h;

DOI:10.1016/S0223-5234(01)01285-5

Reference yield:

N1-2-pyrimidyl-p-(benzyloxycarbonylamino)benzenesulfonamide (288066-50-2) → 4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyric acid 2-[(4-benzyloxycarbonylamino-benzenesulfonyl)-(1,4,5,6-tetrahydro-pyrimidin-2-yl)-amino]-ethyl ester

Guidance literature:

Multi-step reaction with 3 steps

1.1: aq. NaOH

1.2: dimethylformamide / 8 h / 80 °C

2.1: DCC; pyridine / 48 h / 20 °C

3.1: cyclohexene / 10 percent Pd/C / CHCl₃ / 18 h / Heating

With pyridine; sodium hydroxide; dicyclohexyl-carbodiimide; cyclohexene; palladium on activated charcoal; In chloroform;

DOI:10.1016/S0960-894X(01)00157-3

Reference yield:

2-bromoethanol (540-51-2) + N1-2-pyrimidyl-p-(benzyloxycarbonylamino)benzenesulfonamide (288066-50-2) → 2-[N1-2-pyrimidinyl-p-(benzyloxycarbonylamino)benzenesulfonamido]ethanol (288066-52-4)

Guidance literature:

N¹-2-pyrimidyl-p-(benzyloxycarbonylamino)benzenesulfonamide; With sodium hydroxide;

2-bromoethanol; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

DOI:10.1016/S0960-894X(01)00157-3

upstream raw materials:

sulfadiazine

benzyl chloroformate

Downstream raw materials:

2-[N¹-2-pyrimidinyl-p-(benzyloxycarbonylamino)benzenesulfonamido]ethanol

4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyric acid 2-[(4-benzyloxycarbonylamino-benzenesulfonyl)-pyrimidin-2-yl-amino]-ethyl ester