5-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile

Base Information

Chemical Name:5-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile
CAS No.:1624604-05-2
Molecular Formula:C₁₈H₁₃F₅N₄O
Molecular Weight:396.319
Hs Code.:

Synonyms:5-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile

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Chemical Property of 5-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile

Chemical Property:

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Technology Process of 5-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile

There total 10 articles about 5-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.9%

: 1620828-88-7
(4S,6S)-4-(5-bromo-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 3-cyanopyridine-5-boronic acid pinacol ester

: 497147-93-0
3-cyanopyridine-5-boronic acid

: 1624604-05-2
5-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile

Guidance literature:: With caesium carbonate; In tetrahydrofuran; hexane; water; ethyl acetate;

Reference yield:

: 1600511-51-0
1-(5-bromo-2-fluorophenyl)-2-fluoroethan-1-one

: 1624604-05-2
5-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: tetrahydrofuran; ethyl acetate; water

2: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

3: sodium borohydrid; ammonia / tetrahydrofuran; methanol

4: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

5: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

6: hydrogenchloride / ethyl acetate; 1,4-dioxane

7: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

8: ethyl acetate

9: caesium carbonate / tetrahydrofuran; ethyl acetate; water; hexane

With hydrogenchloride; n-butyllithium; sodium borohydrid; triethanolamine; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; caesium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; hexane; acetic acid methyl ester; water; ethyl acetate; acetonitrile;

Reference yield:

: (R,E)-N-(1-(5-bromo-2-fluorophenyl)-2-fluoroethylidene)-2-methylpropane-2-sulfinamide

: 1624604-05-2
5-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

2: sodium borohydrid; ammonia / tetrahydrofuran; methanol

3: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

4: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

5: hydrogenchloride / ethyl acetate; 1,4-dioxane

6: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

7: ethyl acetate

8: caesium carbonate / tetrahydrofuran; ethyl acetate; water; hexane

With hydrogenchloride; n-butyllithium; sodium borohydrid; triethanolamine; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; caesium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; hexane; acetic acid methyl ester; water; ethyl acetate; acetonitrile;