1-[3-(4-Acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile

Base Information

Chemical Name:1-[3-(4-Acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile
CAS No.:131950-22-6
Molecular Formula:C₃₀H₃₀F₂N₂O₃
Molecular Weight:504.577
Hs Code.:

Synonyms:1-[3-(4-Acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile

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Chemical Property of 1-[3-(4-Acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile

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Technology Process of 1-[3-(4-Acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile

There total 3 articles about 1-[3-(4-Acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 131912-08-8
α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile

: 131950-22-6
1-[3-(4-Acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile

Guidance literature:: With potassium carbonate; potassium iodide; In butan-1-ol; Heating;
DOI:10.1021/jm00114a009

Reference yield: 57.5%

: 67-56-1
methanol

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 131912-08-8
α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile

: 131950-22-6
1-[3-(4-Acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile

Guidance literature:: With potassium iodide; potassium carbonate; In chloroform; ethyl acetate; butan-1-ol;

Reference yield:

: 131912-07-7
α,α-bis(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-3-pyrrolidineacetonitrile

: 131950-22-6
1-[3-(4-Acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-pyrrolidineacetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: phenol, 48percent aq. HBr / 3.5 h / Heating

2: 68 percent / K₂CO₃, KI / butan-1-ol / Heating

With hydrogen bromide; potassium carbonate; potassium iodide; phenol; In butan-1-ol;
DOI:10.1021/jm00114a009