Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn

Base Information

• Chemical Name: Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn
• CAS No.: 1352089-56-5
• Molecular Formula: C₆₂H₆₈F₂N₁₄O₁₅
• Molecular Weight: 1287.3
• Mol file: 1352089-56-5.mol

Synonyms:Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn

Chemical Property of Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn

There total 12 articles about Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Boc-Aeg(C[z])-Aeg(H)-Aeg(G[z])-OBn (1352089-55-4) + (2,4-Difluoro-5-methylphenyl)acetic acid (367955-02-0) → Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn (1352089-56-5)

Guidance literature:

(2,4-Difluoro-5-methylphenyl)acetic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere;

Boc-Aeg(C[z])-Aeg(H)-Aeg(G[z])-OBn; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/hlca.201100243

Reference yield:

benzyl N-(2-aminoethyl)glycinate ditosylate → Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn (1352089-56-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5.33 h / 0 - 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: triethylsilane / dichloromethane / 3 h / 0 - 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: triethylsilane / dichloromethane / 3 h / 0 - 20 °C

6.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

6.2: 20 °C / Inert atmosphere

7.1: diethylamine / dichloromethane / 1.5 h / 20 °C

8.1: bromo-tris-dimethylamino-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / tetrahydrofuran / 2 h / 20 °C

10.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

10.2: 20 °C / Inert atmosphere

With triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.201100243

Reference yield:

benzyl N-(2-(N-(allyloxycarbonyl)-N-(2-(N-(2-(4-(benzyloxycarbonylamino)-2-oxopyrimidin-1-yl)acetyl)-N-(2-(tert-butoxycarbonylamino)ethyl)glycylamino)ethyl)glycylamino)ethyl)-N-((9H-fluoren-9-yl)methyloxycarbonyl)glycinate (1352089-52-1) → Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn (1352089-56-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diethylamine / dichloromethane / 1.5 h / 20 °C

2.1: bromo-tris-dimethylamino-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / tetrahydrofuran / 2 h / 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.201100243

upstream raw materials:

benzyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate

H-Aeg(Fmoc)-OBn*TFA

benzyl N-{2-[N-(2-tert-butoxycarbonylaminoethyl)-N-(prop-2-en-1-yloxycarbonyl)]glycylaminoethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

benzyl N-(2-(N-(allyloxycarbonyl)-N-(2-(N-(2-(4-(benzyloxycarbonylamino)-2-oxopyrimidin-1-yl)acetyl)-N-(2-(tert-butoxycarbonylamino)ethyl)glycylamino)ethyl)glycylamino)ethyl)-N-((9H-fluoren-9-yl)methyloxycarbonyl)glycinate