Technology Process of Nebicapone
There total 8 articles about Nebicapone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; aluminium trichloride;
In
ethyl acetate;
at 77 ℃;
for 2h;
DOI:10.1081/SCC-120002413
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93 percent / diethyl ether; tetrahydrofuran / 1 h / 20 °C
2: 91 percent / NaO-tBu; cyclohexanone / toluene / 0.5 h / Heating
3: 94 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating
4: 71 percent / 70percent HNO3; AcOH / 0.5 h / 20 °C
5: 99 percent / AlCl3; pyridine / ethyl acetate / 2 h / Heating
With
pyridine; aluminium trichloride; ammonium formate; cyclohexanone; acetic acid; sodium t-butanolate;
10percent Pd/C;
In
tetrahydrofuran; methanol; diethyl ether; ethyl acetate; toluene;
2: Oppenauer oxidation;
DOI:10.1021/jm0109964
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 94 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating
2: 71 percent / 70percent HNO3; AcOH / 0.5 h / 20 °C
3: 99 percent / AlCl3; pyridine / ethyl acetate / 2 h / Heating
With
pyridine; aluminium trichloride; ammonium formate; acetic acid;
10percent Pd/C;
In
methanol; ethyl acetate;
DOI:10.1021/jm0109964
