(S)-5-benzhydryl-2-(2,6-dimethoxyphenyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium chloride

Base Information

Chemical Name:(S)-5-benzhydryl-2-(2,6-dimethoxyphenyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium chloride
CAS No.:1447813-77-5
Molecular Formula:C₂₆H₂₆N₃O₂*Cl
Molecular Weight:447.964
Hs Code.:

Synonyms:(S)-5-benzhydryl-2-(2,6-dimethoxyphenyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium chloride

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Chemical Property of (S)-5-benzhydryl-2-(2,6-dimethoxyphenyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium chloride

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Technology Process of (S)-5-benzhydryl-2-(2,6-dimethoxyphenyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium chloride

There total 4 articles about (S)-5-benzhydryl-2-(2,6-dimethoxyphenyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447823-11-1
(S,Z)-2-benzhydryl-5-(2-(2,6-dimethoxyphenyl)hydrazono)pyrrolidine hydrochloride

: 122-51-0
orthoformic acid triethyl ester

: 1447813-77-5
(S)-5-benzhydryl-2-(2,6-dimethoxyphenyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium chloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; chlorobenzene; at 120 ℃; for 2h; Inert atmosphere;
DOI:10.1002/chem.201202432

Reference yield:

: 98-79-3
L-Pyroglutamic acid

: 1447813-77-5
(S)-5-benzhydryl-2-(2,6-dimethoxyphenyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium chloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 0 - 20 °C / Inert atmosphere

2.1: magnesium; iodine / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

2.2: 0 - 20 °C / Inert atmosphere

3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / -20 - 20 °C / Inert atmosphere

4.1: dichloromethane / 20 °C / Inert atmosphere

5.1: hydrogenchloride / methanol; 1,4-dioxane / 20 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane; chlorobenzene / 2 h / 120 °C / Inert atmosphere

With hydrogenchloride; triethylsilane; thionyl chloride; boron trifluoride diethyl etherate; iodine; magnesium; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chlorobenzene;
DOI:10.1002/chem.201202432

Reference yield:

: 1407186-37-1
(S)-2-benzhydryl-5-methoxy-3,4-dihydro-2H-pyrrole

: 1447813-77-5
(S)-5-benzhydryl-2-(2,6-dimethoxyphenyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium chloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; 1,4-dioxane / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; chlorobenzene / 2 h / 120 °C / Inert atmosphere

With hydrogenchloride; In 1,4-dioxane; methanol; chlorobenzene;
DOI:10.1002/chem.201202432