Acetic acid (1R,3R,4S)-4-(2-diethylamino-1-nitro-ethyl)-3-methyl-3-vinyl-cyclohexyl ester

Base Information

Chemical Name:Acetic acid (1R,3R,4S)-4-(2-diethylamino-1-nitro-ethyl)-3-methyl-3-vinyl-cyclohexyl ester
CAS No.:73719-50-3
Molecular Formula:C₁₇H₃₀N₂O₄
Molecular Weight:326.436
Hs Code.:

Synonyms:Acetic acid (1R,3R,4S)-4-(2-diethylamino-1-nitro-ethyl)-3-methyl-3-vinyl-cyclohexyl ester

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Chemical Property of Acetic acid (1R,3R,4S)-4-(2-diethylamino-1-nitro-ethyl)-3-methyl-3-vinyl-cyclohexyl ester

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Technology Process of Acetic acid (1R,3R,4S)-4-(2-diethylamino-1-nitro-ethyl)-3-methyl-3-vinyl-cyclohexyl ester

There total 8 articles about Acetic acid (1R,3R,4S)-4-(2-diethylamino-1-nitro-ethyl)-3-methyl-3-vinyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 487-51-4
4-carbethoxy-3-methyl-2-cyclohexen-1-one

: 73719-50-3
Acetic acid (1R,3R,4S)-4-(2-diethylamino-1-nitro-ethyl)-3-methyl-3-vinyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 65 percent / tetrahydrofuran / 0.5 h / -78 °C

2: 67 percent / lithium aluminum hydride / tetrahydrofuran / 1.) 0 deg C; 2.) room temp., 6 h

3: 82 percent / pyridine / 1.) 0 deg C; 2.) room temp., 6 h

4: 83 percent / pyridine / 10 h / Ambient temperature

5: 85 percent / sodium iodide / acetone / 10 h / Heating

6: 29 percent / sodium nitrite / dimethylformamide / 15 h / 80 °C

With lithium aluminium tetrahydride; sodium iodide; sodium nitrite; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo01310a026

Reference yield:

: 74842-04-9
1-ethenyl-5-hydroxy-2-(hydroxymethyl)-1-methylcyclohexane

: 73719-50-3
Acetic acid (1R,3R,4S)-4-(2-diethylamino-1-nitro-ethyl)-3-methyl-3-vinyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / pyridine / 1.) 0 deg C; 2.) room temp., 6 h

2: 83 percent / pyridine / 10 h / Ambient temperature

3: 85 percent / sodium iodide / acetone / 10 h / Heating

4: 29 percent / sodium nitrite / dimethylformamide / 15 h / 80 °C

With sodium iodide; sodium nitrite; In pyridine; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo01310a026

Reference yield:

: 74842-06-1
5-acetoxy-1-ethenyl-2-(iodomethyl)-1-methylcyclohexane

: 73719-50-3
Acetic acid (1R,3R,4S)-4-(2-diethylamino-1-nitro-ethyl)-3-methyl-3-vinyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 29 percent / sodium nitrite / dimethylformamide / 15 h / 80 °C

With sodium nitrite; In N,N-dimethyl-formamide;
DOI:10.1021/jo01310a026