3-(2'-pyridin-4-yl-8',9'-dihydro-7'h-spiro[1,3-dioxolane-2,6'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

Base Information

Chemical Name:3-(2'-pyridin-4-yl-8',9'-dihydro-7'h-spiro[1,3-dioxolane-2,6'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol
CAS No.:1184103-22-7
Molecular Formula:C₂₃H₂₀N₄O₃
Molecular Weight:400.437
Hs Code.:

Synonyms:3-(2'-pyridin-4-yl-8',9'-dihydro-7'h-spiro[1,3-dioxolane-2,6'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

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Chemical Property of 3-(2'-pyridin-4-yl-8',9'-dihydro-7'h-spiro[1,3-dioxolane-2,6'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

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Technology Process of 3-(2'-pyridin-4-yl-8',9'-dihydro-7'h-spiro[1,3-dioxolane-2,6'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

There total 8 articles about 3-(2'-pyridin-4-yl-8',9'-dihydro-7'h-spiro[1,3-dioxolane-2,6'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1184103-65-8
3-(3-hydroxyphenyl)-2-pyridin-4-yl-8,9-dihydropyrazolo[1,5-a]quinazolin-6(7H)-one

: 107-21-1
ethylene glycol

: 1184103-22-7
3-(2'-pyridin-4-yl-8',9'-dihydro-7'h-spiro[1,3-dioxolane-2,6'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

Guidance literature:: With toluene-4-sulfonic acid; orthoformic acid triethyl ester; In dichloromethane; for 1h; Molecular sieve;

Reference yield:

: 19924-43-7
3-methoxyphenylacetonitrile

: 1184103-22-7
3-(2'-pyridin-4-yl-8',9'-dihydro-7'h-spiro[1,3-dioxolane-2,6'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol; sodium / 4 h / 45 °C / Reflux

2: trichlorophosphate / 18 h / 80 °C

3: hydrazine hydrate / ethanol / 6.5 h / Reflux

4: acetic acid / 1 h / 100 °C

5: boron tribromide / dichloromethane / 0 - 20 °C

6: toluene-4-sulfonic acid; orthoformic acid triethyl ester / dichloromethane / 1 h / Molecular sieve

With ethanol; sodium; boron tribromide; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; orthoformic acid triethyl ester; trichlorophosphate; In ethanol; dichloromethane;

Reference yield:

: 85302-07-4
2-(dimethylaminomethylene)cyclohexane-1,3-dione

: 1184103-22-7
3-(2'-pyridin-4-yl-8',9'-dihydro-7'h-spiro[1,3-dioxolane-2,6'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 1 h / 100 °C

2: boron tribromide / dichloromethane / 0 - 20 °C

3: toluene-4-sulfonic acid; orthoformic acid triethyl ester / dichloromethane / 1 h / Molecular sieve

With boron tribromide; toluene-4-sulfonic acid; acetic acid; orthoformic acid triethyl ester; In dichloromethane;