1'-cyclopentyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

Base Information

• Chemical Name: 1'-cyclopentyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one
• CAS No.: 1426688-78-9
• Molecular Formula: C₂₇H₂₉FN₄O
• Molecular Weight: 444.552
• Mol file: 1426688-78-9.mol

Synonyms:1'-cyclopentyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

Chemical Property of 1'-cyclopentyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1'-cyclopentyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

There total 5 articles about 1'-cyclopentyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one (1426688-71-2) + cyclopentanone (120-92-3) → 1'-cyclopentyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one (1426688-78-9)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; Sealed tube;

Reference yield:

tert-butyl 2-oxospiro[indoline-3,3’-pyrrolidine]-1'-carboxylate (205383-87-5) → 1'-cyclopentyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one (1426688-78-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 20 °C

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.17 h / 160 °C / Microwave irradiation; Sealed tube

3: trifluoroacetic acid / 2 h / 20 °C

4: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C / Sealed tube

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; water; acetonitrile;

Reference yield:

tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate (1426689-05-5) → 1'-cyclopentyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one (1426688-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.17 h / 160 °C / Microwave irradiation; Sealed tube

2: trifluoroacetic acid / 2 h / 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C / Sealed tube

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; water;

upstream raw materials:

1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

cyclopentanone

tert-butyl 2-oxospiro[indoline-3,3’-pyrrolidine]-1'-carboxylate

4-bromo-2-fluorobenzyl bromide