8-{4-[3-(4-fluoro-phenyl)-prop-2-ynyloxy]-phenyl}-1-propyl-2-(3-trifluoromethyl-phenyl)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

Base Information

Chemical Name:8-{4-[3-(4-fluoro-phenyl)-prop-2-ynyloxy]-phenyl}-1-propyl-2-(3-trifluoromethyl-phenyl)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one
CAS No.:1243707-91-6
Molecular Formula:C₃₆H₃₆F₄N₄O₃Si
Molecular Weight:676.786
Hs Code.:

Synonyms:8-{4-[3-(4-fluoro-phenyl)-prop-2-ynyloxy]-phenyl}-1-propyl-2-(3-trifluoromethyl-phenyl)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

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Chemical Property of 8-{4-[3-(4-fluoro-phenyl)-prop-2-ynyloxy]-phenyl}-1-propyl-2-(3-trifluoromethyl-phenyl)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

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Technology Process of 8-{4-[3-(4-fluoro-phenyl)-prop-2-ynyloxy]-phenyl}-1-propyl-2-(3-trifluoromethyl-phenyl)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

There total 8 articles about 8-{4-[3-(4-fluoro-phenyl)-prop-2-ynyloxy]-phenyl}-1-propyl-2-(3-trifluoromethyl-phenyl)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1243707-90-5
8-(4-hydroxy-phenyl)-1-propyl-2-(3-trifluoromethyl-phenyl)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

: 40274-29-1
1-(3-bromoprop-1-yn-1-yl)-4-fluorobenzene

: 1243707-91-6
8-{4-[3-(4-fluoro-phenyl)-prop-2-ynyloxy]-phenyl}-1-propyl-2-(3-trifluoromethyl-phenyl)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

Guidance literature:: With potassium carbonate; In acetone; at 60 ℃; for 2h;

Reference yield:

: 1486-51-7
p-(benzyloxy)benzoic acid

: 1243707-91-6
8-{4-[3-(4-fluoro-phenyl)-prop-2-ynyloxy]-phenyl}-1-propyl-2-(3-trifluoromethyl-phenyl)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 20 h / 20 - 25 °C

2: phosphorus pentachloride; trichlorophosphate / 20 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

4: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 28 h / 80 - 90 °C / Degasation

5: ammonium formate / palladium 10% on activated carbon / N,N-dimethyl-formamide; water / 2 h / 80 °C

6: potassium carbonate / acetone / 2 h / 60 °C

With phosphorus pentachloride; ammonium formate; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1243707-74-5
N-(6-amino-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-4-benzyloxy-benzamide

: 1243707-91-6
8-{4-[3-(4-fluoro-phenyl)-prop-2-ynyloxy]-phenyl}-1-propyl-2-(3-trifluoromethyl-phenyl)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: phosphorus pentachloride; trichlorophosphate / 20 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 28 h / 80 - 90 °C / Degasation

4: ammonium formate / palladium 10% on activated carbon / N,N-dimethyl-formamide; water / 2 h / 80 °C

5: potassium carbonate / acetone / 2 h / 60 °C

With phosphorus pentachloride; ammonium formate; sodium hydrogencarbonate; potassium carbonate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;