(RS)-N-4-chlorophenyl-N'-(6-formamido-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea

Base Information

Chemical Name:(RS)-N-4-chlorophenyl-N'-(6-formamido-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea
CAS No.:1314406-33-1
Molecular Formula:C₁₉H₂₀ClN₃O₂S
Molecular Weight:389.906
Hs Code.:

Synonyms:(RS)-N-4-chlorophenyl-N'-(6-formamido-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea

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Chemical Property of (RS)-N-4-chlorophenyl-N'-(6-formamido-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea

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Technology Process of (RS)-N-4-chlorophenyl-N'-(6-formamido-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea

There total 10 articles about (RS)-N-4-chlorophenyl-N'-(6-formamido-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 64-18-6
formic acid

: 1314406-29-5
(RS)-N-4-chlorophenyl-N'-(6-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea

: 1314406-33-1
(RS)-N-4-chlorophenyl-N'-(6-formamido-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea

Guidance literature:: formic acid; With acetic anhydride; at 55 ℃; for 2h;

(RS)-N-4-chlorophenyl-N'-(6-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea; In tetrahydrofuran;
DOI:10.1016/j.bmc.2011.05.040

Reference yield:

: 1314406-17-1
6-tert-butyloxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-one

: 1314406-33-1
(RS)-N-4-chlorophenyl-N'-(6-formamido-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 3 h / Reflux

2.1: hydrogen / methanol / 3750.38 Torr

3.1: dichloromethane / 0.5 h

4.1: hydrogenchloride / ethanol / 0.08 h / Reflux

4.2: pH 10

5.1: acetic anhydride / 2 h / 55 °C

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; acetic anhydride; potassium carbonate; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2011.05.040

Reference yield:

: 186774-62-9
6-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-one

: 1314406-33-1
(RS)-N-4-chlorophenyl-N'-(6-formamido-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrahydrofuran; water / 96 h / 25 °C

2.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 3 h / Reflux

3.1: hydrogen / methanol / 3750.38 Torr

4.1: dichloromethane / 0.5 h

5.1: hydrogenchloride / ethanol / 0.08 h / Reflux

5.2: pH 10

6.1: acetic anhydride / 2 h / 55 °C

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; acetic anhydride; potassium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.05.040