(1S,2R)-1-phenyl-2-[(S)-1-tert-butoxycarbonylaminopropyl]-N,N-diethylcyclopropanecarboxamide

Base Information

Chemical Name:(1S,2R)-1-phenyl-2-[(S)-1-tert-butoxycarbonylaminopropyl]-N,N-diethylcyclopropanecarboxamide
CAS No.:473775-39-2
Molecular Formula:C₂₂H₃₄N₂O₃
Molecular Weight:374.524
Hs Code.:

Synonyms:(1S,2R)-1-phenyl-2-[(S)-1-tert-butoxycarbonylaminopropyl]-N,N-diethylcyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-1-phenyl-2-[(S)-1-tert-butoxycarbonylaminopropyl]-N,N-diethylcyclopropanecarboxamide

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Technology Process of (1S,2R)-1-phenyl-2-[(S)-1-tert-butoxycarbonylaminopropyl]-N,N-diethylcyclopropanecarboxamide

There total 1 articles about (1S,2R)-1-phenyl-2-[(S)-1-tert-butoxycarbonylaminopropyl]-N,N-diethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 171889-07-9
(1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide

: 473775-39-2
(1S,2R)-1-phenyl-2-[(S)-1-tert-butoxycarbonylaminopropyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 14h;
DOI:10.1039/b111540p

Reference yield: 92.0%

: 473775-39-2
(1S,2R)-1-phenyl-2-[(S)-1-tert-butoxycarbonylaminopropyl]-N,N-diethylcyclopropanecarboxamide

: 74-88-4
methyl iodide

: 473775-40-5
[(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: (1S,2R)-1-phenyl-2-[(S)-1-tert-butoxycarbonylaminopropyl]-N,N-diethylcyclopropanecarboxamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -15 ℃;

methyl iodide; In tetrahydrofuran; hexane; at -15 ℃; for 1h; Further stages.;
DOI:10.1039/b111540p

Reference yield:

: 473775-39-2
(1S,2R)-1-phenyl-2-[(S)-1-tert-butoxycarbonylaminopropyl]-N,N-diethylcyclopropanecarboxamide

: (1S,2R)-1-phenyl-2-[(S)-1-(N-methylamino)propyl]-N,N-diethylcyclopropanecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran; hexane / -78 - -15 °C

1.2: 92 percent / tetrahydrofuran; hexane / 1 h / -15 °C

2.1: 95 percent / aq. HCl / methanol / 1 h / Heating

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; methanol; hexane;
DOI:10.1039/b111540p