methyl-1-(phenoxycarbonyl)-4-(2,5-difluorobenzyl)-1,4-dihydronicotinate

Base Information

• Chemical Name: methyl-1-(phenoxycarbonyl)-4-(2,5-difluorobenzyl)-1,4-dihydronicotinate
• CAS No.: 188439-66-9
• Molecular Formula: C₂₁H₁₇F₂NO₄
• Molecular Weight: 385.367
• Mol file: 188439-66-9.mol

Synonyms:methyl-1-(phenoxycarbonyl)-4-(2,5-difluorobenzyl)-1,4-dihydronicotinate

Chemical Property of methyl-1-(phenoxycarbonyl)-4-(2,5-difluorobenzyl)-1,4-dihydronicotinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-1-(phenoxycarbonyl)-4-(2,5-difluorobenzyl)-1,4-dihydronicotinate

There total 5 articles about methyl-1-(phenoxycarbonyl)-4-(2,5-difluorobenzyl)-1,4-dihydronicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-pyridinecarboxylate (93-60-7) → methyl-1-(phenoxycarbonyl)-4-(2,5-difluorobenzyl)-1,4-dihydronicotinate (188439-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 0 °C

2: 1.) Zn / 1.) THF, RT, 4 h, 2.) THF, 0 deg C, 1 h

With zinc; In tetrahydrofuran;

DOI:10.1002/jhet.5570350328

Reference yield:

phenyl chloroformate (1885-14-9) → methyl-1-(phenoxycarbonyl)-4-(2,5-difluorobenzyl)-1,4-dihydronicotinate (188439-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 0 °C

2: 1.) Zn / 1.) THF, RT, 4 h, 2.) THF, 0 deg C, 1 h

With zinc; In tetrahydrofuran;

DOI:10.1002/jhet.5570350328

Reference yield:

3-Methoxycarbonyl-1-phenoxycarbonyl-pyridinium; chloride + 2-(bromomethyl)-1,4-difluorobenzene (85117-99-3) → methyl-1-(phenoxycarbonyl)-4-(2,5-difluorobenzyl)-1,4-dihydronicotinate (188439-66-9)

Guidance literature:

With zinc; Yield given. Multistep reaction; 1.) THF, RT, 4 h, 2.) THF, 0 deg C, 1 h;

DOI:10.1002/jhet.5570350328

upstream raw materials:

2-(bromomethyl)-1,4-difluorobenzene

methyl 3-pyridinecarboxylate

phenyl chloroformate

Downstream raw materials:

methyl-4-(2,5-difluorobenzyl)nicotinate

4-(2,5-Difluoro-benzyl)-pyridine-3-carbaldehyde

[4-(2,5-Difluoro-benzyl)-pyridin-3-yl]-methanol