N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[2-oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-acetamide

Base Information

• Chemical Name: N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[2-oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-acetamide
• CAS No.: 147283-89-4
• Molecular Formula: C₃₂H₄₂F₃N₅O₄Si
• Molecular Weight: 645.797
• Mol file: 147283-89-4.mol

Synonyms:N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[2-oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-acetamide

Chemical Property of N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[2-oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[2-oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-acetamide

There total 3 articles about N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[2-oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide (147269-02-1) → N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[2-oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-acetamide (147283-89-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 5 h / 760 Torr

2: Et₃N / CH₂Cl₂ / 0.75 h / 0 °C

3: CH₂Cl₂ / 0 - 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00046a016

Reference yield:

2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide (147283-34-9) → N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[2-oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-acetamide (147283-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0.75 h / 0 °C

2: CH₂Cl₂ / 0 - 20 °C

With triethylamine; In dichloromethane;

DOI:10.1021/jm00046a016

Reference yield:

3-Aminomethylpyridine (3731-52-0) + (1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid trichloromethyl ester → N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[2-oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-acetamide (147283-89-4)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm00046a016

upstream raw materials:

3-Aminomethylpyridine

2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

Downstream raw materials:

2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide

2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide