Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide

Base Information

• Chemical Name: Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide
• CAS No.: 86662-09-1
• Molecular Formula: C₂₀H₂₃BrClN₃O₃S₂
• Molecular Weight: 532.91
• Mol file: 86662-09-1.mol

Synonyms:Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide

Chemical Property of Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide

There total 4 articles about Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

morpholine (110-91-8,99108-56-2) + N-(2-Bromo-ethyl)-N-(4-chloro-2-isothiocyanato-phenyl)-4-methyl-benzenesulfonamide (345936-77-8) → Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide (86662-09-1)

Guidance literature:

In diethyl ether; for 0.166667h; Heating;

DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

N-(4-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide (3968-03-4) → Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide (86662-09-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) NaOMe / 1) methanol, reflux, 2) DMF, 120 deg C

2: H₂ / 8percent Pd-C / dioxane / Ambient temperature

3: H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

4: 83 percent / diethyl ether / 0.17 h / Heating

With hydrogen; sodium methylate; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; water;

DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

N-(2-bromoethyl)-4'-chloro-2'-nitro-p-toluenesulfonanilide (86661-97-4) → Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide (86662-09-1)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 8percent Pd-C / dioxane / Ambient temperature

2: H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

3: 83 percent / diethyl ether / 0.17 h / Heating

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; water;

DOI:10.1016/S0040-4020(01)91886-1

upstream raw materials:

morpholine

N-(2-Bromo-ethyl)-N-(4-chloro-2-isothiocyanato-phenyl)-4-methyl-benzenesulfonamide

N-(4-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide

N-(2-Amino-4-chloro-phenyl)-N-(2-bromo-ethyl)-4-methyl-benzenesulfonamide

Downstream raw materials:

(Z)-3-Chloro-6-morpholin-4-yl-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocyclooctene