ethyl (5R)-5-[1-(tert-Butyl)-1,1-diphenylsilyl]oxy-3-oxo-7-phenylheptanoate

Base Information

Chemical Name:ethyl (5R)-5-[1-(tert-Butyl)-1,1-diphenylsilyl]oxy-3-oxo-7-phenylheptanoate
CAS No.:936716-29-9
Molecular Formula:C₃₁H₃₈O₄Si
Molecular Weight:502.726
Hs Code.:

Synonyms:ethyl (5R)-5-[1-(tert-Butyl)-1,1-diphenylsilyl]oxy-3-oxo-7-phenylheptanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (5R)-5-[1-(tert-Butyl)-1,1-diphenylsilyl]oxy-3-oxo-7-phenylheptanoate

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Technology Process of ethyl (5R)-5-[1-(tert-Butyl)-1,1-diphenylsilyl]oxy-3-oxo-7-phenylheptanoate

There total 10 articles about ethyl (5R)-5-[1-(tert-Butyl)-1,1-diphenylsilyl]oxy-3-oxo-7-phenylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 623-73-4
diazoacetic acid ethyl ester

: 936716-28-8
(3R)-3-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-5-phenylpentanal

: 936716-29-9
ethyl (5R)-5-[1-(tert-Butyl)-1,1-diphenylsilyl]oxy-3-oxo-7-phenylheptanoate

Guidance literature:: With tin(ll) chloride; In dichloromethane; at 0 - 20 ℃; for 0.666667h;
DOI:10.1055/s-2007-965904

Reference yield:

: C₁₀H₁₆O₃

: 936716-29-9
ethyl (5R)-5-[1-(tert-Butyl)-1,1-diphenylsilyl]oxy-3-oxo-7-phenylheptanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: CuI; Ph₃P; potassium carbonate / Pd/C / 1,2-dimethoxy-ethane; H₂O / 0.5 h / 20 °C

1.2: 90 percent / 1,2-dimethoxy-ethane; H₂O / 2 h / 80 °C

2.1: 90 percent / H₂ / Pd/C / ethyl acetate / 6 h / 20 °C

3.1: 95 percent / imidazole / CH₂Cl₂ / 2 h / 0 °C

4.1: 90 percent / pyridinium p-toluenesulfonate / methanol / 2 h / 20 °C

5.1: 90 percent / 2-iodoxybenzoic acid / dimethylsulfoxide; CH₂Cl₂ / 2 h / 20 °C

6.1: 80 percent / tin(II) chloride / CH₂Cl₂ / 0.67 h / 0 - 20 °C

With 1H-imidazole; copper(l) iodide; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; triphenylphosphine; tin(ll) chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1055/s-2007-965904

Reference yield:

: 936716-24-4
(3S)-1-phenyl-5-(tetrahydro-2H-2-pyranyloxy)pent-1-yn-3-ol

: 936716-29-9
ethyl (5R)-5-[1-(tert-Butyl)-1,1-diphenylsilyl]oxy-3-oxo-7-phenylheptanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / H₂ / Pd/C / ethyl acetate / 6 h / 20 °C

2: 95 percent / imidazole / CH₂Cl₂ / 2 h / 0 °C

3: 90 percent / pyridinium p-toluenesulfonate / methanol / 2 h / 20 °C

4: 90 percent / 2-iodoxybenzoic acid / dimethylsulfoxide; CH₂Cl₂ / 2 h / 20 °C

5: 80 percent / tin(II) chloride / CH₂Cl₂ / 0.67 h / 0 - 20 °C

With 1H-imidazole; hydrogen; pyridinium p-toluenesulfonate; tin(ll) chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1055/s-2007-965904