methyl 1,2-dihydroxy-1-(4-benzyloxy-3-methoxy)-phenylpropanoate

Base Information

• Chemical Name: methyl 1,2-dihydroxy-1-(4-benzyloxy-3-methoxy)-phenylpropanoate
• CAS No.: 213595-69-8
• Molecular Formula: C₁₈H₂₀O₆
• Molecular Weight: 332.353
• Mol file: 213595-69-8.mol

Synonyms:methyl 1,2-dihydroxy-1-(4-benzyloxy-3-methoxy)-phenylpropanoate

Chemical Property of methyl 1,2-dihydroxy-1-(4-benzyloxy-3-methoxy)-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1,2-dihydroxy-1-(4-benzyloxy-3-methoxy)-phenylpropanoate

There total 4 articles about methyl 1,2-dihydroxy-1-(4-benzyloxy-3-methoxy)-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methyl (E)-3-[4-(benzyloxy)-3-methoxyphenyl]acrylate (93878-20-7) → methyl 1,2-dihydroxy-1-(4-benzyloxy-3-methoxy)-phenylpropanoate (213595-69-8)

Guidance literature:

With AD-mix-α; methanesulfonamide; In water; tert-butyl alcohol; at 0 ℃;

DOI:10.1080/00397919808004916

Reference yield:

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid (1135-24-6,537-98-4) → methyl 1,2-dihydroxy-1-(4-benzyloxy-3-methoxy)-phenylpropanoate (213595-69-8)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether

2: K₂CO₃ / acetone / 24 h / 20 °C

3: 65 percent / AD-mix-α; metanesulfonamide / H2O; 2-methyl-propan-2-ol / 0 °C

With AD-mix-α; methanesulfonamide; potassium carbonate; In diethyl ether; water; acetone; tert-butyl alcohol; 1: Esterification / 2: Substitution / 3: Oxidation;

DOI:10.1080/00397919808004916

Reference yield:

Methyl ferulate (2309-07-1) → methyl 1,2-dihydroxy-1-(4-benzyloxy-3-methoxy)-phenylpropanoate (213595-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / 24 h / 20 °C

2: 65 percent / AD-mix-α; metanesulfonamide / H2O; 2-methyl-propan-2-ol / 0 °C

With AD-mix-α; methanesulfonamide; potassium carbonate; In water; acetone; tert-butyl alcohol; 1: Substitution / 2: Oxidation;

DOI:10.1080/00397919808004916

upstream raw materials:

methyl (E)-3-[4-(benzyloxy)-3-methoxyphenyl]acrylate

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Methyl ferulate

benzyl bromide

Downstream raw materials:

(1S,2S)-1-(4-benzyloxy-3-methoxyphenyl)-2,3-dihydroxypropanol

2-methoxy-4-[(1′S,2′S)-1′,2′,3′-trihydroxypropyl]phenol