benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate
CAS No.:1200575-65-0
Molecular Formula:C₂₈H₂₈INO₆S
Molecular Weight:633.504
Hs Code.:

Synonyms:benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

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Chemical Property of benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

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Technology Process of benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

There total 5 articles about benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1200572-71-9
benzyl 4-{6-[2-amino-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

: 1200575-65-0
benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

Guidance literature:: benzyl 4-{6-[2-amino-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate; With hydrogenchloride; sodium nitrite; In water; acetonitrile; at 0 ℃; for 0.333333h;

With potassium iodide; In water; acetonitrile; at 20 ℃; for 2h;

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1200575-65-0
benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / chloroform / 3 h / Molecular sieve; Dean-Stark apparatus; Reflux

2.1: potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 1 h / 90 °C

2.2: 15 h / 90 °C

3.1: indium; ammonium chloride / methanol / 15 h / 85 °C

4.1: hydrogenchloride; sodium nitrite / water; acetonitrile / 0.33 h / 0 °C

4.2: 2 h / 20 °C

With hydrogenchloride; indium; potassium acetate; ammonium chloride; toluene-4-sulfonic acid; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; sodium nitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; 1,2-dimethoxyethane; chloroform; water; acetonitrile;

Reference yield:

: 1200575-51-4
benzyl 4-(6-bromo-4H-1,3-benzodioxin-2-yl)piperidine-1-carboxylate

: 1200575-65-0
benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 1 h / 90 °C

1.2: 15 h / 90 °C

2.1: indium; ammonium chloride / methanol / 15 h / 85 °C

3.1: hydrogenchloride; sodium nitrite / water; acetonitrile / 0.33 h / 0 °C

3.2: 2 h / 20 °C

With hydrogenchloride; indium; potassium acetate; ammonium chloride; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; sodium nitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; 1,2-dimethoxyethane; water; acetonitrile;